Injectable clostridial collagenase is a promising treatment for patients with Dupuytren contracture. Dose-ranging, phase 2 clinical trials identified an optimal collagenase dose of 10,000 units (0.58 mg), balancing excellent clinical…
Fig. 8.1 Dupuytren myofibroblasts. (a) Immunofluorescence staining of Dupuytren myofibroblasts in a 3D collagen matrix. Cell matrix junctions stained for integrin β1 (red), F actin (phalloidin) (green) and nuclei stained…
Fig. 12.1 From genotype to phenotype. Human genetic studies of Dupuytren Disease aim to identify the underlying genetic variation (genotype) contributing to the etiology of the disease (phenotype). The disease…
Fig. 2.1 The rate of surgery for Dupuytren contracture in the 143 NHS hospitals in England. The figure shows the different rates per 100,000 population, not standardised for age or…
© Springer International Publishing Switzerland 2017Paul M. N. Werker, Joseph Dias, Charles Eaton, Bert Reichert and Wolfgang Wach (eds.)Dupuytren Disease and Related Diseases – The Cutting Edge10.1007/978-3-319-32199-8_1 1. Treatment of Dupuytren Disease in Different Countries: A Welcome Address…
Fig. 12.1 Accepted metabolic effects of AMPK in skeletal muscle. AMPK is activated by several metabolic stresses such as energy depletion, myokines, adipokines, oxidative stress, and Ca2+ release from sarcoplasmic…
Author, year Journal, volume, pages Manner of analysis Results Species Andrianjafiniony etal. [41] Am J Physiol Cell Physiol 299: C307–C315 Western blot Beclin-1 protein ⇔ Mouse Liu et al. [42]…
Fig. 6.1 Overview on the synthesis of the large (60S) and small (40S) subunits of the ribosome. RPs ribosomal proteins Ribosome biogenesis is intimately linked to cell growth and proliferation…
Fig. 1.1 Methods for derivation of human embryonic stem cells (hESCs) from samples coming from anonymous donations of processes such as in vitro fertilization or the injection of sperm into…
Fig. 11.1 ROS regulation of transcription factors and expression of proteins involved in promoting the reduction of fiber size due to disuse. Based on published findings, we propose a list…
