Chapter 48 New Treatments in Systemic Lupus Erythematosus Vasileios C. Kyttaris, MD , George C. Tsokos, MD INTRODUCTION Immunosuppressive therapy, the main treatment modality for severe lupus, has been effective…
Chapter 45 Systemic Steroids Mustafa Al-Maini, MD , Murray Urowitz, MD INTRODUCTION Corticosteroid medications are found in the therapeutic armamentarium of most medical specialties. Rheumatologists have had a long relationship…
Chapter 38 Overlap Syndromes, Mixed Connective Tissue Disease, and Undifferentiated Connective Tissue Disease Robert W. Hoffman, DO INTRODUCTION Classification of the rheumatic diseases continues to be challenging for a number…
Chapter 42 Neonatal Lupus: Clinical Perspectives Anca D. Askanase, MD, MPH , Jill P. Buyon, MD INTRODUCTION Neonatal lupus (NL) is a model of passive autoimmunity; anti-SSA/Ro-SSB/La antibodies (Ab) cross…
Chapter 22D Antibodies to SSA/Ro and SSB/La: Potential Mechanisms of Tissue Injury in Neonatal Lupus-Congenital Heart Block Jill P. Buyon, MD , Robert M. Clancy, PhD PATHOGENESIS: LAYING THE GROUNDWORK…
Chapter 22C Antineuronal Antibodies John G. Hanly, MD INTRODUCTION Autoantibody production is a cardinal feature in the pathogenesis of systemic lupus erythematosus (SLE) and is associated with most of the…
Chapter 22G Anti-Spliceosomal Autoantibodies Edward K.L. Chan, PhD , Carol Peebles, MS, MT , Marvin J. Fritzler, MD, PhD , Minoru Satoh, MD, PhD INTRODUCTION Anti-Sm was one of the…
Chapter 47 Treatment of Antiphospholipid Syndrome Munther A. Khamashta, MD, FRCP, PhD INTRODUCTION Antiphospholipid syndrome (APS) is defined by the development of thrombosis and/or adverse obstetric events in the presence…
Chapter 44 Nonsteroid Treatment of Systemic Lupus Erythematosus Robert G. Lahita, MD, PhD INTRODUCTION There has not been a new treatment approved for systemic lupus erythematosus (SLE) in over 25…
