Mechanisms of Skin Damage
Chapter 28 Mechanisms of Skin Damage Markus Böhm, MD , Thomas A. Luger, MD INTRODUCTION Understanding the mechanisms of skin damage in cutaneous lupus erythematosus (CLE) requires knowledge of the…
Systemic Lupus Erythematosus and Infections
Chapter 35 Systemic Lupus Erythematosus and Infections William R. Gilliland, MD , George C. Tsokos, MD Despite improved treatment and overall survival of patients with systemic lupus erythematosus (SLE), infection…
The Heart and Systemic Lupus Erythematosus
Chapter 32 The Heart and Systemic Lupus Erythematosus Jennifer R. Elliott, MD , Amy H. Kao, MD, MPH , Susan Manzi, MD, MPH INTRODUCTION Systemic lupus erythematosus (SLE, lupus) is…
Nitric Oxide in Systemic Lupus Erythematosus
Chapter 26 Nitric Oxide in Systemic Lupus Erythematosus James C. Oates, MD , Gary S. Gilkeson, MD INTRODUCTION Whereas acquired autoimmunity is the sine qua non of lupus, the innate…
Anti-Histone Antibodies in Systemic Lupus Erythematosus
Chapter 22E Anti-Histone Antibodies in Systemic Lupus Erythematosus Georg Schett, MD , Günter Steiner, MD , Josef S. Smolen, MD INTRODUCTION The autoimmune response to chromatin is one of the…
The Lung in Systemic Lupus Erythematosus
Chapter 33 The Lung in Systemic Lupus Erythematosus Rapti Mediwake, MD , Roland M. du Bois, Elliott INTRODUCTION Systemic lupus erythematosus (SLE) can affect all parts of the respiratory system,…
Systemic Lupus Erythematosus and Vasculitis
Chapter 27 Systemic Lupus Erythematosus and Vasculitis Tsutomu Takeuchi, MD INTRODUCTION Vasculitis is defined as the inflammation and necrosis of vessel walls as a primary process or as a complication…
The Nervous System in Systemic Lupus Erythematosus
Chapter 37 The Nervous System in Systemic Lupus Erythematosus John G. Hanly, MD INTRODUCTION Although neurological (N) and psychiatric (P) events are frequently encountered in patients with systemic lupus erythematosus…
Cytotoxic Drug Treatment
Chapter 46 Cytotoxic Drug Treatment Eva D. Papadimitraki, MD , Dimitrios T. Boumpas, MD, FACP INTRODUCTION Cytotoxic agents were initially introduced for their ability to interrupt nucleic acid and protein…
Gastrointestinal Disease in Systemic Lupus Erythematosus
Chapter 34 Gastrointestinal Disease in Systemic Lupus Erythematosus Chi Chiu Mok, MD, FRCP INTRODUCTION Gastrointestinal (GI) manifestations of systemic lupus erythematosus (SLE) are protean. Any part of the GI tract,…
