Ectopic Fat Accumulation and Glucose Homeostasis: Role of Leptin in Glucose and Lipid Metabolism and Mass Maintenance in Skeletal Muscle
Fig. 14.1 Schematic representation of the leptin’s effects on glucose and lipid metabolism in skeletal muscle Recent studies have extended our understanding of the role of leptin in obesity and…
Mechanism of Skeletal Muscle Contraction: Role of Mechanical Muscle Contraction in Glucose Homeostasis
Fig. 11.1 Glucose uptake in the leg during a cycling exercise in type 2 diabetic patients and healthy controls (Modified from Martin et al. [3]) Muscle contraction also improves whole-body…
Sarcopenia in Diabetes Mellitus
Fig. 16.1 Interaction between sarcopenia and diabetes. Insulin resistance in skeletal muscle is the most important link between sarcopenia and diabetes. Sarcopenia and obesity appear to have additive effects on…
Clinical Application of Exercise Therapy in Diabetes with Chronic Kidney Disease
Fig. 19.1 Intradialytic exercise program (i.e., exercise during dialysis sessions). a Aerobic exercise using a recumbent cycle ergometer. b Strength training using ankle weights Exercise professionals often need to be…
Clinical Application of Exercise Therapy in Diabetes
Fig. 18.1 Exercise therapy application criteria for patients with diabetes; after careful medical check, exercise prescription on the type, time, intensity, and frequency must be ordered according to the degree…
Mechanism for the Development of Bone Disease in Diabetes: Increased Oxidative Stress and Advanced Glycation End Products
Fig. 5.1 Effects of the AGE-RAGE axis on osteoblasts 5.5 AGE-RAGE Axis and Osteoclasts There is some controversy about the pathological role of AGEs in osteoclast function in osteoporosis. Miyata…
Mechanism of Skeletal Muscle Contraction: Intracellular Signaling in Skeletal Muscle Contraction
Fig. 10.1 Proposed model of exercise-induced signaling pathway in the skeletal muscle. Classified into three signaling pathways: AMP-activated protein kinase (AMPK), Ca2+, and mitogen-activated protein kinase (MAPK). AMPK is activated…
Bone Disease Associated with Diabetes Mellitus: Particularly Focusing on Its Contribution to the Development of Atherosclerosis
© Springer Japan 2016Masaaki Inaba (ed.)Musculoskeletal Disease Associated with Diabetes Mellitus10.1007/978-4-431-55720-3_1 1. Bone Disease Associated with Diabetes Mellitus: Particularly Focusing on Its Contribution to the Development of Atherosclerosis Masaaki Inaba1 (1) Department of Metabolism, Endocrinology…
Mechanism for the Development of Bone Disease in Diabetes: Abnormal Glucose Metabolism
Study, year [ref] N Sex Duration Design Intervention HbA1c, % Metabolic bone markers PTH 25(OH)D IGF-1 Others M/F Baseline End CTX NTX DPD BAP P1NP OC Gregorio, 1994 [27] 50…
