Chapter 17 What Do Mouse Models Teach Us about Human Systemic Lupus Erythematosus? Kui Liu, PhD , Chandra Mohan, MD, PhD INTRODUCTION Systemic lupus erythematosus (SLE) is an autoimmune disease…
Chapter 15 Infection and Autoimmunity Brian D. Poole, PhD , Judith A. James, MD, PhD Infections are associated with both the etiology and morbidity of systemic lupus erythematosus (SLE). Mounting…
Chapter 8 The Genetics of Lupus Bahram Namjou, MD , Jennifer A. Kelly, MPH , John B. Harley, MD, PhD INTRODUCTION Systemic lupus erythematosus (SLE) is the prototypic systemic autoimmune…
Chapter 18 Genes and Genetics of Murine Lupus Shozo Izui, MD INTRODUCTION Systemic lupus erythematosus (SLE) is a disorder of systemic autoimmunity characterized by the formation of a variety of…
Chapter 21 Immune Complexes in Systemic Lupus Erythematosus Mark H. Wener, MD INTRODUCTION Antigen-antibody complexes mediate much of the inflammation and tissue dysfunction associated with SLE. Deposition of ICs within…
Chapter 16 Autoantibodies in Systemic Lupus Erythematosus David Isenberg, MD , Matthew Adler, MRCP INTRODUCTION Overview of Autoantibodies in SLE One of the hallmarks of systemic lupus erythematosus (SLE) is…
Chapter 20 Role of Complement in Systemic Lupus Erythematosus Pathogenesis Chau-Ching Liu, MD, PhD , Jeannine S. Navratil, MS , Amy H. Kao, MD, MPH , Susan Manzi, MD, MPH…
Chapter 19 Complement Deficiencies in Human Systemic Lupus Erythematosus (SLE) and SLE Nephritis: Epidemiology and Pathogenesis C. Yung Yu, Dphil , Georges Hauptmann, MD, PhD , Yan Yang, MD, PhD…
Chapter 13 Biology of Dendritic Cells Virginia Pascual, MD , A. Karolina Palucka, MD , Jacques Banchereau, MD INTRODUCTION The primary role of the immune system is to protect the…
Chapter 22A Antibodies to DNA David S. Pisetsky, MD, PhD INTRODUCTION Antibodies to DNA (anti-DNA) are prototypic autoantibodies that are the serologic hallmark of systemic lupus erythematosus (SLE). These antibodies…
