Juvenile Idiopathic Arthritis

Jun 30, 2019 by in RHEUMATOLOGY Comments Off on Juvenile Idiopathic Arthritis

Arthritis is one of the most common chronic diseases of children and youth, and an important cause of short- and long-term disability. There are many causes of chronic arthritis, but…

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Pharmacology and Drug Therapy: Nonbiologic Therapies

Jun 30, 2019 by in RHEUMATOLOGY Comments Off on Pharmacology and Drug Therapy: Nonbiologic Therapies

The principal drugs used in pediatric rheumatology are drugs that suppress the inflammatory and immune responses. This chapter outlines important general principles relating to these medications, particularly as they apply…

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Pain and Its Assessment

Jun 30, 2019 by in RHEUMATOLOGY Comments Off on Pain and Its Assessment

Chronic or intermittent pain is a primary symptom of many pediatric rheumatic diseases, especially arthritis. Patients often report mild to moderate pain. About 25% to 30% report moderate to severe…

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Pharmacology: Biologics

Jun 30, 2019 by in RHEUMATOLOGY Comments Off on Pharmacology: Biologics

Biologics are different from nonbiologic disease-modifying antirheumatic drugs (DMARDs) in that they are produced by biologic processes rather than chemical syntheses and target specific, well-defined molecules expressed on cells or…

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Managing Children with Rheumatic Diseases

Jun 30, 2019 by in RHEUMATOLOGY Comments Off on Managing Children with Rheumatic Diseases

Rheumatic diseases are chronic, multisystem disorders characterized by an unpredictable course with periods of exacerbation and remission. Optimal care requires the expertise of many disciplines ( Table 11-1 , Fig….

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Inflammation and Its Mediators

Jun 30, 2019 by in RHEUMATOLOGY Comments Off on Inflammation and Its Mediators

The immune system, the function of which is to protect against infections, comprises two branches: a more primitive one called innate (natural, native) immunity and the more recently evolved one…

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Structure and Function

Jun 30, 2019 by in RHEUMATOLOGY Comments Off on Structure and Function

Inflammation, the fundamental pathologic process in rheumatic diseases, may disrupt the anatomy and function of any structure or tissue. Those structures primarily affected in rheumatic diseases are the connective tissues,…

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