Bony Manifestations of Renal Osteodystrophy
Radiographic examination of the skull may show irregular rarefaction of the calvaria (“salt-and-pepper” skull) and loss of the dense white line cast by the lamina dura surrounding the roots of…
Rickets, Osteomalacia, and Renal Osteodystrophy
The biochemical alterations in renal osteodystrophy can be summarized as follows: 1. Azotemia, hyperphosphatemia, and changes in acid-base balance and electrolytes that reflect the chronic acidotic state 2. Low serum…
Metabolic Aberrations of Renal Osteodystrophy
Treatment of rachitic and osteomalacic syndromes due to renal tubular acidosis should focus on the primary process rather than on the bone disease. Administration of alkali in the form of…
Vitamin D–Resistant Rickets and Osteomalacia due to Renal Tubular Acidosis
Rickets or osteomalacia of variable degrees is a common manifestation of all the diverse conditions associated with renal tubular acidosis. Some of the rachitic disorders are life threatening, such as…
Vitamin D–Resistant Rickets and Osteomalacia due to Proximal and Distal Renal Tubular Defects
Three phosphate-wasting lesions in the proximal tubule have been identified. Type I, first described by Albright, is seen most frequently. It is transmitted as a sex-linked dominant trait and the…
Vitamin D–Dependent (Pseudodeficiency) Rickets and Osteomalacia
All of the findings and chemical abnormalities are similar to those seen in the classic nutritional deficiency syndrome, with the exception of the concentrations of the polar metabolites of vitamin…
Nutritional Deficiency: Rickets and Osteomalacia
ADULT OSTEOMALACIA Clinical Manifestations. The diagnosis of adult osteomalacia (see Plate 3-14) may be difficult to establish because the changes may be considerably more subtle than those seen in childhood…
Vitamin D–Resistant Rickets and Osteomalacia due to Proximal Renal Tubular Defects (Hypophosphatemic Rachitic Syndromes)
Vitamin D has receptors throughout many tissues and acts as both an endocrine as well as an autocrine/paracrine hormone. The endocrine properties have direct effects on bone and muscle tissue…
Adult Osteomalacia
CHILDHOOD RICKETS Clinical Manifestations. In severe childhood rickets (see Plate 3-13), growth is impaired and height is generally below the third quartile. However, unless there is concurrent severe nutritional disturbance,…
Clinical Guide to Parathyroid Hormone Assay (Continued)
In summary, the advent of totally automated immunometric I-PTH assays has led to improved accurate clinical discrimination of parathyroid disorders and has provided a tool to measure PTH levels in…
