The Future of ANCA-associated Vasculitis

Oct 1, 2017 by in RHEUMATOLOGY Comments Off on The Future of ANCA-associated Vasculitis

The introduction of cyclophosphamide for treatment and the detection of antineutrophil cytoplasmatic antibodies (ANCA) as a seromarker for ANCA-associated vasculitis (AAV) have been the most important milestones in the history…

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Outcome Measures in ANCA-associated Vasculitis

Oct 1, 2017 by in RHEUMATOLOGY Comments Off on Outcome Measures in ANCA-associated Vasculitis

The outcome in patients with antineutrophil cytoplasm antibody (ANCA)-associated vasculitis has considerably improved with the use of potent immunosuppression. In the most severe cases, mortality remains an important risk despite…

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Pauci-Immune Necrotizing Glomerulonephritis

Oct 1, 2017 by in RHEUMATOLOGY Comments Off on Pauci-Immune Necrotizing Glomerulonephritis

Pauci-immune necrotizing glomerulonephritis is the most frequent cause of rapidly progressive glomerulonephritis and, in most cases, is associated with antineutrophil cytoplasmic antibodies (ANCA). It is either the renal manifestation of…

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Ocular Manifestations of ANCA-associated Vasculitis

Oct 1, 2017 by in RHEUMATOLOGY Comments Off on Ocular Manifestations of ANCA-associated Vasculitis

The antineutrophil cytoplasmic antibody (ANCA)-associated vasculitides—Wegener’s granulomatosis, microscopic polyangiitis, and Churg-Strauss syndrome—can present with various ophthalmic manifestations. In a subset of patients, these findings may be the earliest indicators of…

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Microscopic Polyangiitis

Oct 1, 2017 by in RHEUMATOLOGY Comments Off on Microscopic Polyangiitis

In 1923, Friedrich Wohlwill described two patients with a “microscopic form of periarteritis nodosa,” which was distinct from the classical form. This disease, now known as microscopic polyangiitis (MPA), is…

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Diagnostic Approach to ANCA-associated Vasculitides

Oct 1, 2017 by in RHEUMATOLOGY Comments Off on Diagnostic Approach to ANCA-associated Vasculitides

Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitides (AAV) include Wegener’s granulomatosis, microscopic polyangiitis, and Churg-Strauss syndrome. Given their rarity, protean clinical manifestations, imperfect diagnostic tests, and wide differential diagnosis, they pose a diagnostic…

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Autoantibodies in ANCA-associated Vasculitis

Oct 1, 2017 by in RHEUMATOLOGY Comments Off on Autoantibodies in ANCA-associated Vasculitis

Antineutrophil cytoplasmic autoantibody (ANCA)-associated vasculitides are systemic or more limited conditions characterized by necrotizing destruction of small and medium-sized vessels (eg, capillaries, venules, and arterioles). ANCAs are the most predominant…

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Pathogenesis of ANCA-associated Vasculitis

Oct 1, 2017 by in RHEUMATOLOGY Comments Off on Pathogenesis of ANCA-associated Vasculitis

Antineutrophil cytoplasm antibody (ANCA)-associated vasculitis (AAV) comprises a group of systemic inflammatory vasculitides associated with circulating autoantibodies directed against the neutrophil granule components proteinase 3 and myeloperoxidase. ANCA interact with…

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