The Response of Cartilage to Injury

Nov 27, 2016 by in RHEUMATOLOGY Comments Off on The Response of Cartilage to Injury

Fig. 11.1 Toluidine blue staining of a cartilage biopsy specimen overlying a bone bruise harvested from an ACL-injured patient before ACL reconstruction (from [6]). This specimen was histologically graded as…

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Potential Mechanisms of PTA: Cell Death

Nov 27, 2016 by in RHEUMATOLOGY Comments Off on Potential Mechanisms of PTA: Cell Death

Fig. 15.1 Overview of cell death-related pathways. Extrinsic apoptosis involving death receptors and extracellular ligands leads to the activation of caspases. Inhibition of caspases is mediated by various molecules including…

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In Vitro Cartilage Explant Injury Models

Nov 27, 2016 by in RHEUMATOLOGY Comments Off on In Vitro Cartilage Explant Injury Models

Fig. 4.1 A load-controlled test apparatus to apply single or cyclic loads to multiple cartilage specimens. (A) Pneumatic air pistons to load the explants. (B) Piston rod with flat-bottom, cylindrical,…

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Unanswered Questions and Future Directions in Post-Traumatic Arthritis

Nov 27, 2016 by in RHEUMATOLOGY Comments Off on Unanswered Questions and Future Directions in Post-Traumatic Arthritis

© Springer Science+Business Media New York 2015Steven A. Olson, MD and Farshid Guilak, PhD (eds.)Post-Traumatic Arthritis10.1007/978-1-4899-7606-2_28 28. Unanswered Questions and Future Directions in Post-Traumatic Arthritis Steven A. Olson1   and Farshid Guilak2   (1) Department of Orthopedic Surgery, Duke University…

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Stem Cell Therapies for Post-Traumatic Arthritis

Nov 27, 2016 by in RHEUMATOLOGY Comments Off on Stem Cell Therapies for Post-Traumatic Arthritis

Title: A phase I/II, randomized, controlled, double-blind, study of chondrogen—adult universal cell delivered by intra-articular injection following meniscectomy in patients 18–60 years ClinicalTrials.gov Identifier: NCT00225095 Sponsor: Mesoblast International Sàrl Purpose:…

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