Measurement of Severity of Injury After Articular Fracture and Correlation with Post-Traumatic Arthritis Development

Nov 27, 2016 by in RHEUMATOLOGY Comments Off on Measurement of Severity of Injury After Articular Fracture and Correlation with Post-Traumatic Arthritis Development

Fig. 24.1 These radiographs illustrate the tibial plafond fracture severity spectrum. Simple intra-articular fractures result from low energy impacts (left). As energy increases (moving from left to right in the…

read more

Potential Mechanisms of PTA: Oxidative Stress

Nov 27, 2016 by in RHEUMATOLOGY Comments Off on Potential Mechanisms of PTA: Oxidative Stress

Fig. 17.1 Blunt impact suppresses cartilage ATP production. Explant cartilage was harvested for ATP assay 24 or 48 h postimpact (7 J/cm2). Cartilage was harvested from control (non-impacted) explants and…

read more

Instability: Dynamic Loading Models

Nov 27, 2016 by in RHEUMATOLOGY Comments Off on Instability: Dynamic Loading Models

Fig. 9.1 Dynamic human cadaveric ankle loading model in which ankles were made incongruous with a coronally directed osteotomy of the anterior distal tibial surface displaced proximally 2.0 mm (a)….

read more

Biomarkers of PTA

Nov 27, 2016 by in RHEUMATOLOGY Comments Off on Biomarkers of PTA

Fig. 25.1 Framework for PTOA Pathomechanics. Modified from: Andriacchi and Mundermann 2006 [13] Pre-injury biomarker generation. As illustrated in Fig. 25.1, biomarker generation may begin in the pre-injury phase among…

read more

Aging and Post-Traumatic Arthritis

Nov 27, 2016 by in RHEUMATOLOGY Comments Off on Aging and Post-Traumatic Arthritis

Fig. 14.1 Systemic aging changes that could contribute to the development of osteoarthritis, including post-traumatic OA. Reprinted with permission from HSS Journal 2012; 8:19 Relationship Between Age and the Development…

read more

The Response of the Subchondral Bone to Injury

Nov 27, 2016 by in RHEUMATOLOGY Comments Off on The Response of the Subchondral Bone to Injury

Fig. 12.1 Histologic cross section of a normal knee joint (Courtesy of Edward DiCarlo, MD, Hospital for Special Surgery, New York, NY) Under physiological conditions, the subchondral bone adapts its…

read more

Genetic Variability in the Response to Injury

Nov 27, 2016 by in RHEUMATOLOGY Comments Off on Genetic Variability in the Response to Injury

First author Year Mouse strain Phenotype Outcome Reference Fitzgerald 2008 MRL/MpJ Knee articular cartilage defects, ear wounds Able to heal full-thickness knee articular cartilage defects, able to heal 2-mm ear…

read more
Get Clinical Tree app for offline access