Laboratory and the Pediatric Rheumatologist

Oct 25, 2017 by in RHEUMATOLOGY Comments Off on Laboratory and the Pediatric Rheumatologist

Fig. 10.1 Indirect immunofluorescence assay: (a) homogeneous pattern of ANA, (b) cytoplasmic pattern of ANCA Antinuclear antibodies target different antigens, and assessing the sub-specificities of ANA can give some clue…

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Immunodeficiency and Rheumatic Diseases

Oct 25, 2017 by in RHEUMATOLOGY Comments Off on Immunodeficiency and Rheumatic Diseases

Categories Examples Humoral (antibody) deficiencies X-linked agammaglobulinemia (XLA) Common variable immunodeficiencies (CVID) Hyper-IgM syndromes Combined immunodeficiencies Severe combined immunodeficiencies (SCID) Complete DiGeorge syndrome Phagocytic defects Severe congenital neutropenia (SCN) Chronic…

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Clinical Case Vignettes: Vasculitis

Oct 25, 2017 by in RHEUMATOLOGY Comments Off on Clinical Case Vignettes: Vasculitis

Fig. 42.1 Purpuric papules over the tip of the toes in a 9-year-old girl Complete blood count, prothrombin time, partial thromboplastin time, and fibrinogen level were within normal limits. The…

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Infections and Arthritis in Childhood

Oct 25, 2017 by in RHEUMATOLOGY Comments Off on Infections and Arthritis in Childhood

Fig. 21.1 Sweling around lateral malleolus of right ankle with MRI of the region and ulcreated positive Mantoux test. (a) The arrow shows swelling and erythema around the lateral malleolus….

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Outcome Measures in Pediatric Rheumatology

Oct 25, 2017 by in RHEUMATOLOGY Comments Off on Outcome Measures in Pediatric Rheumatology

Disease status Parameters to be fulfilled per the JIA subcategory Inactive disease No active arthritis No fever, rash, serositis, splenomegaly, or generalized lymphadenopathy attributable to JIA No active uveitis Normal…

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Transition: Moving from Pediatric to Adult Rheumatology Care

Oct 25, 2017 by in RHEUMATOLOGY Comments Off on Transition: Moving from Pediatric to Adult Rheumatology Care

Pediatric Adult Triadic or family consultation Dyadic or individual consultation Assumes patient dependence Assumes patient independence Multidisciplinary team Limited multidisciplinary team Consultation time longer Consultation time shorter Procedural pain management…

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Biologic Response Modifiers in Pediatric Rheumatology

Oct 25, 2017 by in RHEUMATOLOGY Comments Off on Biologic Response Modifiers in Pediatric Rheumatology

© Springer Science+Business Media Singapore 2017Sujata Sawhney and Amita Aggarwal (eds.)Pediatric Rheumatology10.1007/978-981-10-1750-6_8 8. Biologic Response Modifiers in Pediatric Rheumatology Alessandro Consolaro1   and Nicola Ruperto2   (1) Istituto Giannina Gaslini, University of Genova and Second Division of Pediatrics, Genova,…

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Nonbiologic Drugs in Pediatric Rheumatology

Oct 25, 2017 by in RHEUMATOLOGY Comments Off on Nonbiologic Drugs in Pediatric Rheumatology

Drug Dose (mg/kg/day unless otherwise noted) Maximal dose (mg/day) Doses per day Remarks Acetylsalicylic acid (ASA) 80–100 (<25 kg); 2500 mg/m2 (>25 kg) Antiplatelet dose 3–5 mg/kg/day single dose 4900…

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