Pearls • Increased survival from pediatric critical illness has been accompanied by an increase in both short- and long-term morbidities for children undergoing active neurocognitive development. • The harms of…
Pearls • Acute severe hypertension, defined as significant blood pressure (BP) elevation with or without evidence of acute hypertensive target-organ damage, requires prompt therapy to prevent and/or ameliorate further target-organ…
Pearls • Patients receiving renal replacement therapy (RRT) require careful monitoring of fluid and electrolyte balance and nutritional needs. • Coordination between the critical care and nephrology staff is essential…
Pearls • Cellular respiration is largely coordinated in the mitochondria and normally aligns energy demand with energy production. In critical illness, disruption of cellular bioenergetic homeostasis may be a final…
• Unexpected and unexplained clinical deterioration in a previously healthy infant or child is an important clue to the presence of an inborn error of metabolism (IEM). • Loss of…
Pearls • Acute kidney injury (AKI) has replaced the term acute kidney failure . There are more than 30 definitions of AKI in children. Use of the pediatric Risk, Injury,…
Pearls • There are distinct differences in the pediatric and adult airway, including the fact that the infant airway is situated higher in the neck (between the second and fourth…
Pearls • Serum creatinine is a crude assessment of filtration, influenced by several factors other than glomerular function, including gender, age, muscle mass, dilution, concentration relative to steady state, lack…
Pearls • There are four distinct phases of cardiac arrest and cardiopulmonary resuscitation (CPR): prearrest, no-flow (untreated cardiac arrest), low-flow (CPR), and postarrest. • The most common precipitating event for…
Pearls • The kidney is the primary elimination pathway for the majority of medications. Thus, understanding appropriate dosing for patients in acute and chronic renal impairment is imperative to avoid…
