Fig. 3.1 Prior to and during OIF/OND and OEF, frequencies of medical discharge due to osteoarthritis have stayed nearly the same. However, back, upper, and lower extremity conditions have resulted…
© Springer Science+Business Media New York 2015Steven A. Olson, MD and Farshid Guilak, PhD (eds.)Post-Traumatic Arthritis10.1007/978-1-4899-7606-2_28 28. Unanswered Questions and Future Directions in Post-Traumatic Arthritis Steven A. Olson1 and Farshid Guilak2 (1) Department of Orthopedic Surgery, Duke University…
Title: A phase I/II, randomized, controlled, double-blind, study of chondrogen—adult universal cell delivered by intra-articular injection following meniscectomy in patients 18–60 years ClinicalTrials.gov Identifier: NCT00225095 Sponsor: Mesoblast International Sàrl Purpose:…
Drugs Mechanism of action In vitro effect on chondrocytes Pathology used for Effects reported in clinical studies Country performed at Oral vitamin E Antioxidant Improved chondrocyte viability Prevention of knee…
Nonoperative NSAIDs Physical therapy Aquatic therapy Operative Hip arthrodesis PTA Knee: Nonoperative Let us assume for a moment that the treatment of osteoarthritis of the knee can be translated to…
Positively Negatively Anatomic reduction Posterior wall involvement Congruent joint reduction Articular step-off >2 mm Age <40 years Femoral head involvement/dislocation Age >55–60 years Intra-articular fracture fragmentation Osteonecrosis Fracture displacement >10–20…
© Springer Science+Business Media New York 2015Steven A. Olson, MD and Farshid Guilak, PhD (eds.)Post-Traumatic Arthritis10.1007/978-1-4899-7606-2_16 16. Potential Mechanisms of PTOA: Inflammation Mary B. Goldring1 (1) Research Division, Tissue Engineering, Regeneration and Repair Program, The Hospital for…
Strain ACL-T type Surgery age Exp. time Results Reference Unknown Stab incision Unknown 1–26 weeks OA changes in articular cartilage (fibrillation, loss of cells in superficial layer); synovitis subsides within…
© Springer Science+Business Media New York 2015Steven A. Olson, MD and Farshid Guilak, PhD (eds.)Post-Traumatic Arthritis10.1007/978-1-4899-7606-2_2 2. Post-Traumatic Arthritis: Definitions and Burden of Disease Joseph A. Buckwalter1, 2 and David T. Felson3 (1) Department of Orthopedics and Rehabilitation, University…
Fig. 10.1 Summary of outcomes for models of PTA for the mouse, rabbit, and dog. To demonstrate variability in the development of PTA for a small, mid-sized, and large animal…
