Chapter 22D Antibodies to SSA/Ro and SSB/La: Potential Mechanisms of Tissue Injury in Neonatal Lupus-Congenital Heart Block Jill P. Buyon, MD , Robert M. Clancy, PhD PATHOGENESIS: LAYING THE GROUNDWORK…
Chapter 22C Antineuronal Antibodies John G. Hanly, MD INTRODUCTION Autoantibody production is a cardinal feature in the pathogenesis of systemic lupus erythematosus (SLE) and is associated with most of the…
Chapter 22G Anti-Spliceosomal Autoantibodies Edward K.L. Chan, PhD , Carol Peebles, MS, MT , Marvin J. Fritzler, MD, PhD , Minoru Satoh, MD, PhD INTRODUCTION Anti-Sm was one of the…
Chapter 47 Treatment of Antiphospholipid Syndrome Munther A. Khamashta, MD, FRCP, PhD INTRODUCTION Antiphospholipid syndrome (APS) is defined by the development of thrombosis and/or adverse obstetric events in the presence…
Chapter 44 Nonsteroid Treatment of Systemic Lupus Erythematosus Robert G. Lahita, MD, PhD INTRODUCTION There has not been a new treatment approved for systemic lupus erythematosus (SLE) in over 25…
Chapter 41 Fertility in Systemic Lupus Erythematosus Michael D. Lockshin, MD INTRODUCTION Infertility, of either sex, is the inability to create an embryo. In patients with systemic lupus erythematosus (SLE),…
Chapter 36 Hematologic and Coagulation Abnormalities of Systemic Lupus Erythematosus and the Antiphospholipid Syndrome E. Nigel Harris, MD , Wendell A. Wilson, MD , Silvia S. Pierangeli, PhD INTRODUCTION Hematologic…
Chapter 29 Constitutional Features of Systemic Lupus Erythematosus Caroline Gordon, MA, MD, FRCP INTRODUCTION Constitutional features are a common but rather nonspecific aspect of SLE. This chapter will review the…
Chapter 22F Standardization of Autoantibody Testing in Systemic Rheumatic Diseases Marvin J. Fritzler, MD, PhD , Alan Wiik, MD, PhD INTRODUCTION Autoantibody testing has become a powerful tool for clinicians…
Chapter 25 Mitochondrial Dysfunction and Oxidative Stress in T Cells of Patients with Systemic Lupus Erythematosus Andras Perl, MD, PhD SUMMARY Activation, proliferation, and cell death pathway selection of T…
