• The typical patient with septic shock has simultaneous derangements of cardiovascular function, intravascular volume status, respiratory function, immune/inflammatory regulation, renal function, coagulation, hepatic function, and/or metabolic function. • The…
• Flumazenil, when used for benzodiazepine overdose, may unmask seizures caused by a coingested substance or precipitate acute withdrawal in the patient who habitually uses benzodiazepines. • β-Adrenergic antagonists, when…
• Approximately 1 child in 250 has a rheumatologic disease. • A child may present to the intensive care unit (ICU) with a life-threatening manifestation of an undiagnosed rheumatologic disease…
• Innate immunity provides the frontline ready-made response to pathogen invasion. • These same pathways are activated in response to other critical insults, including trauma, hypoxic/ischemic injury, and bypass. •…
• Unlike the innate immune response, the adaptive immune response is characterized by specific antigen recognition and immunologic memory. • Lymphocytes are the key cell types of the adaptive immune…
• Provision of individually tailored optimal nutrition is an important goal of pediatric critical care. • Malnutrition is prevalent in the pediatric intensive care unit (PICU) and is associated with…
• Risk factors for malignant hyperthermia (MH) include a family history of severe hyperthermia or sudden hypermetabolic state during anesthesia with exposure to succinylcholine and/or potent inhalation anesthetics, and ryanodine…
Pearls • The classic triad of fever, neck stiffness, and a change in mental status is present in less than 50% of pediatric meningitis cases. • Streptococcus species (particularly viridans…
Pearls • Cardiac arrest in pediatric patients is predominantly due to asphyxia. This is in contrast to adults, for whom, despite an increase in asphyxial cardiac arrest related to the…
In the last 2 decades, there has been a robust demand for outpatient pediatric procedural sedation, now provided by myriad pediatric subspecialists, including pediatric intensivists. , The intensivist who is…
