Nonserious Infections
Nonserious infections (NSIE) as colds, flu syndromes, and urinary tract infection, are the most common infections seen in patients with immune mediated inflammatory diseases. Yet, little is known about the…
Safety of Bisphosphonates
Bisphosphonates are antiresorptive medications widely prescribed for treating osteoporosis. In placebo-controlled clinical trials they have been shown to significantly reduce the risk of osteoporotic fractures. However, reports of atypical femoral…
Communicating the Risk of Side Effects to Rheumatic Patients
When proposing a new therapy, rheumatologists must inform patients of a range of therapeutic options and support them towards making an informed decision. This article introduces definitions of equipoise and…
Safety of Urate-Lowering Therapies
Gout is a metabolic disorder of purine metabolism and uric acid elimination. Over time, acute gout can develop into a chronic, disabling arthropathy, often associated with multiple comorbidities. Gout patients…
Refining Drug Safety in Rheumatology
John J. Cush, MD, Guest Editor Kathryn H. Dao, MD, Guest Editor An exciting era of rheumatology is upon us. Advances in pathobiology have produced novel advances in the treatment…
Nonarthroplasty Hip Surgery for Early Osteoarthritis
The most favorable mechanical environment for the hip is one that is free of both instability and impingement, creating a concentric articulation with optimum femoral head coverage by the acetabulum….
Targeting Care
International evidence-based guidelines recommend a multitude of nonsurgical treatment options for the management of osteoarthritis. This article summarizes the evidence available for patient characteristics that have been analyzed as potential…
Disease Modification
Osteoarthritis (OA) is a significant and growing concern to a large segment of the population. Effective treatments for slowing or stopping the progression of the disease are not available despite…
Surgery for Osteoarthritis of the Knee
Although total knee replacement is an excellent treatment of end-stage osteoarthritis of the knee in the older (>65 years) population, many patients with less severe disease are significantly impacted by…
Update on the Role of Muscle in the Genesis and Management of Knee Osteoarthritis
This updated review outlines the influence of muscle activity on knee joint loading, describes the deficits in muscle function observed in people with knee osteoarthritis, and summarizes available evidence pertaining…
