Osteoporosis in Men: Update 2011
During the past year several review articles have been published on the topic of osteoporosis in men. These reviews have highlighted recommendations for measuring bone mineral density (BMD) in older…
Update on Glucocorticoid-Induced Osteoporosis
Glucocorticoid-induced osteoporosis (GIOP) is the most common form of secondary osteoporosis, and fractures are the most frequent adverse effects of this medication. Glucocorticoids have several direct and indirect adverse effects…
Is There a Place for Bone Turnover Markers in the Assessment of Osteoporosis and its Treatment?
As populations age, the number of osteoporotic fractures will increase. Bone mineral density (BMD) measurement remains the major way to diagnose osteoporosis and to indicate therapy. The FRAX tool, based…
Long-term Safety Concerns of Antiresorptive Therapy
Bisphosphonates reduce the risk of major osteoporotic fractures and are the most commonly used medications for the prevention and treatment of osteoporosis. Although these medications are well tolerated and safe…
Calcium and Vitamin D Controversies
Controversies regarding appropriate use of vitamin D and calcium are predominately related to the extraskeletal effects. Calcium and vitamin D are essential for bone health. The concerns regarding calcium and…
Emerging Therapies for Osteoporosis
This article reviews the conceptual framework for agents that are antiresorptive or anabolic, including pathways that affect bone formation and resorption, and the steps in those pathways that are targets…
Duration of Treatment in Postmenopausal Osteoporosis: How Long to Treat and What are the Consequences of Cessation of Treatment?
Although a variety of medications are effective for the treatment of postmenopausal osteoporosis, there is concern that long-term use may incur side effects. Consequently, some have proposed discontinuing or temporarily…
Neoplasm Mimics of Rheumatologic Presentations: Sialadenitis, Ocular Masquerade Syndromes, Retroperitoneal Fibrosis, and Regional Pain Syndromes
This article reviews a group of miscellaneous malignant conditions that may mimic rheumatologic diseases. Primary salivary gland cancer as well as lymphoproliferative conditions such as lymphoma and IgG4 related syndromes…
Neoplastic and Paraneoplastic Vasculitis, Vasculopathy, and Hypercoagulability
Rheumatologists are often consulted regarding both typical and atypical vasculitides, vasculopathies, and hypercoagulability. It is important to keep in mind that all of these can come from neoplastic or paraneoplastic…
Neoplastic/Paraneoplastic Dermatitis, Fasciitis, and Panniculitis
Changes of the epidermis, dermis, and subcutaneous fat can occur in the setting of internal malignancy. When a particular cutaneous disorder is strongly associated with, and parallels the course of,…
