Study Design and Outcome Measures in Osteoarthritis Clinical Trials Vibeke Strand Marc C. Hochberg The typical patient with osteoarthritis (OA) is middle-aged or elderly and presents with the gradual onset…
Complementary and Alternative Medicine Sharon L. Kolasinski Introduction In 1993, the publication of a survey on the use of what was then termed “unconventional medicine”1 surprised many in the traditional…
Intra-Articular Therapy David H. Neustadt Ray Altman Intra-Articular Steroids in Osteoarthritis In 1951, hydrocortisone was introduced and popularized for local intra-articular administration. Observations and a vast experience accumulated during the…
The Pharmacologic Treatment of Osteoarthritis Lee S. Simon Vibeke Strand Osteoarthritis (OA), a heterogeneous disorder that affects a majority of people older than 60 years, is typically observed as an…
Baseline Program Todd Stitik Marc C. Hochberg An estimated 21 million adults, or 12% of the U.S. population aged 25 to 74 years, have signs and symptoms of osteoarthritis (OA),…
Secondary Osteoarthritis H. Ralph Schumacher Jr. Lan X. Chen Joseph Buckwalter In increasing percentages of patients, osteoarthritis (OA) can now be classified as secondary on the basis of an identifiable…
Noninvasive Biochemical Markers in Osteoarthritis Patrick Garnero Introduction Osteoarthritis (OA) is a highly prevalent age-related disease characterized by an abnormal and degraded cartilage, associated with synovitis and variable subchondral bone…
Magnetic Resonance Imaging Charles G. Peterfy Julie C. DiCarlo Manish Kothari Imaging Osteoarthritis with Magnetic Resonance Imaging For more than two decades, magnetic resonance imaging (MRI) has been the imaging…
Laboratory Findings in Osteoarthritis Roy D. Altman As a clinical entity, osteoarthritis (OA) is a constellation of clinical, radiographic, and synovial fluid findings. To date there are no pathognomonic laboratory…
Ultrasound and Alternative Imaging Outcomes Helen I. Keen Paul Emery Philip G. Conaghan Osteoarthritis (OA) is increasingly common in our aging society. Cartilage is not the only anatomic structure involved…
