Investigational Agents and Future Therapy for SLE
Chapter 56 Investigational Agents and Future Therapy for SLE Georg H. Stummvoll, Josef S. Smolen When Moriz Kaposi1 in 1872 dealt with the therapy of systemic lupus erythematosus (SLE) for…
Overview and Clinical Presentation
Chapter 22 Overview and Clinical Presentation Andrea Hinojosa-Azaola, Jorge Sánchez-Guerrero Systemic lupus erythematosus (SLE) is considered the most clinically and serologically diverse autoimmune disease because it can affect almost any…
Drug-Induced Lupus: Etiology, Pathogenesis, and Clinical Aspects
Chapter 39 Drug-Induced Lupus Etiology, Pathogenesis, and Clinical Aspects Dipak Patel, Bruce Richardson Lupus flares when genetically predisposed people encounter drugs or environmental agents that trigger the disease. Although the…
Hematologic and Lymphoid Abnormalities in SLE
Chapter 34 Hematologic and Lymphoid Abnormalities in SLE George A. Karpouzas Hematologic abnormalities are common in systemic lupus erythematosus (SLE) and are often presenting manifestations of the disease. Sometimes their…
Mortality in SLE
Chapter 57 Mortality in SLE Sasha Bernatsky, Deborah Levy, Rosalind Ramsey-Goldman, Caroline Gordon, Anisur Rahman, Ann E. Clarke It is well known that systemic lupus erythematosus (SLE) can be severe…
Animal Models of SLE
Chapter 17 Animal Models of SLE Bevra Hannahs Hahn, Dwight Kono Animal models of SLE have provided an invaluable resource for defining disease pathophysiology, genetics, and therapeutic approaches. Furthermore, in…
Pathomechanisms of Cutaneous Lupus Erythematosus
Chapter 23 Pathomechanisms of Cutaneous Lupus Erythematosus Jan P. Dutz Abnormal cutaneous reactivity to sunlight is such a seminal clinical feature of lupus erythematosus (LE) that it is one of…
Antimalarial Medications
Chapter 49 Antimalarial Medications J. Antonio Aviña-Zubieta, John M. Esdaile Introduction Paine first used quinine for the treatment of discoid lupus erythematosus.1 It was not, however, until 1951, when Page…
Autoantigenesis and Antigen-Based Therapy and Vaccination in SLE
Chapter 21 Autoantigenesis and Antigen-Based Therapy and Vaccination in SLE Ram Raj Singh, Julia Pinkhasov, Priti Prasad, Shweta Dubey1, The discovery in the early 1990s that self-antigen–reactive T cells can…
The Pathogenesis of SLE
Chapter 3 The Pathogenesis of SLE Bevra H. Hahn The purpose of this brief chapter is to review how SLE evolves and is sustained. Ideas reflect the author’s opinions, which…
