Fig. 40.1 (a) Retracted skin in Dupuytren Disease, wherein myofibroblasts are aligned and anchored to the epidermis (brown staining, Alfa smooth muscle actin stained); (b) in contrast, the noninvolved skin…
PICOS analysis Definition Participants Dupuytren Disease of the hand Intervention Surgical treatment/percutaneous fasciotomy/collagenase injection for DD Comparisons Not applicable (systematic review) Outcomes Reported range of movement Study design Included: RCTs,…
Fig. 18.1 Mean flexion contractures from baseline to day 31 Fig. 18.2 Range of motion at baseline and day 31 Table 18.1 Most common treatment-related AEs AE, n (%) (n…
Fig. 27.1 Tonometry measurement (illustration of the tonometer in use) Two independent assessors measured all patients using the agreed standardised protocol. Nodules to be assessed were identified and agreed by…
Examples of molecules previously identified in the Dupuytren Disease extracellular matrix Structural and nonstructural ECM molecules Matricellular (nonstructural) ECM molecules Growth and differentiation factors Collagens (I, III, + many others)…
Fig. 25.1 Severe contracture of the two ulnar rays 25.3 Treating a Severe PIP Contracture Several problems need to be addressed when treating a severe PIPj contracture. 25.3.1 Skin After…
© Springer International Publishing Switzerland 2017Paul M. N. Werker, Joseph Dias, Charles Eaton, Bert Reichert and Wolfgang Wach (eds.)Dupuytren Disease and Related Diseases – The Cutting Edge10.1007/978-3-319-32199-8_57 57. International Clinical Research – The Australian Perspective: A Personal View…
© Springer International Publishing Switzerland 2017Paul M. N. Werker, Joseph Dias, Charles Eaton, Bert Reichert and Wolfgang Wach (eds.)Dupuytren Disease and Related Diseases – The Cutting Edge10.1007/978-3-319-32199-8_55 55. Patient-Rated Outcome Measures and Dupuytren Contracture Joseph J. Dias1 (1) University Hospitals…
© Springer International Publishing Switzerland 2017Paul M. N. Werker, Joseph Dias, Charles Eaton, Bert Reichert and Wolfgang Wach (eds.)Dupuytren Disease and Related Diseases – The Cutting Edge10.1007/978-3-319-32199-8_54 54. Clinical Research: International Collaboration to Execute High-Powered Clinical Trials Marie A. Badalamente1 …
© Springer International Publishing Switzerland 2017Paul M. N. Werker, Joseph Dias, Charles Eaton, Bert Reichert and Wolfgang Wach (eds.)Dupuytren Disease and Related Diseases – The Cutting Edge10.1007/978-3-319-32199-8_53 53. How Should We Fund Basic Research of Dupuytren Disease? Dominic Furniss1 …
