Pediatric and Neonatal Lupus
Malar rash It is a macular papular rash in the malar area and usually spares the nasolabial folds. This rash tends to be photosensitive and heals without scaring Alopecia It…
Approach to a Child with a Limp
Fig. 15.1 MRI of the right hip shows an osteoid osteoma at the upper metaphyseal end of the right femur This case illustrates several learning points: (a) Many cases of…
Uveitis in Children
Fig. 49.1 Cross section of eye showing areas affected in anterior, intermediate and posterior uveitis and potential complications (in brackets) (Permission obtained from Wiley © Hughes and Dick [4]) In…
Human Joint Anatomy and Physiology
Functional Synarthrosis Immobile or nearly immobile joints (sutures, manubriosternal joints) Amphiarthrosis Limited mobility joints (symphysis pubis, intervertebral joints) Arthrosis Freely movable joints (shoulder, knee) Structural Fibrous joints Adjacent bones are…
Metabolic Bone Disease and Osteoporosis in Children
Anorexia nervosa/female athlete triad Asthma Chondrodysplasias Chronic liver and kidney disease Cushing syndrome Cystic fibrosis Diabetes Ehlers-Danlos syndrome Endocrine disorders Extensive burns Gastrointestinal disorders Gaucher disease Hypophosphatasia Idiopathic juvenile osteoporosis…
Pediatric Takayasu Arteritis
Criterion Definition Age at disease onset less than 40 years Development of symptoms or findings related to Takayasu arteritis at age <40 years Claudication of limbs Development and worsening of…
Granulomatosis with Polyangiitis in Children
Fig. 36.1 Case study 1 – chest radiograph showing bilateral air space opacities consistent with pulmonary hemorrhage Introduction Granulomatosis with polyangiitis (GPA), previously known as Wegener’s granulomatosis [1], is a…
Systemic-Onset Juvenile Idiopathic Arthritis
Koebner phenomenon in a child with SJIA SJIA rash in a 6-year-old girl References 1. Gowdie PJ, Tse SM. Juvenile idiopathic arthritis. Pediatr Clin North Am. 2012;59:301–27.CrossRefPubMed 2. Singh S,…
Laboratory and the Pediatric Rheumatologist
Fig. 10.1 Indirect immunofluorescence assay: (a) homogeneous pattern of ANA, (b) cytoplasmic pattern of ANCA Antinuclear antibodies target different antigens, and assessing the sub-specificities of ANA can give some clue…
Immunodeficiency and Rheumatic Diseases
Categories Examples Humoral (antibody) deficiencies X-linked agammaglobulinemia (XLA) Common variable immunodeficiencies (CVID) Hyper-IgM syndromes Combined immunodeficiencies Severe combined immunodeficiencies (SCID) Complete DiGeorge syndrome Phagocytic defects Severe congenital neutropenia (SCN) Chronic…
