Innate Immunity
18 Innate Immunity Steven A. Porcelli Key Points Innate immunity depends on recognition of conserved molecular patterns found in many microorganisms. Several families of pattern recognition receptors are responsible for…
Acute Phase Reactants and the Concept of Inflammation
57 Acute Phase Reactants and the Concept of Inflammation Amit Saxena, Bruce N. Cronstein Key Points Inflammation comprises a complex and highly variable set of processes that represent a response…
Assessment of Health Outcomes
33 Assessment of Health Outcomes Dorcas E. Beaton, Maarten Boers, Peter Tugwell Key Points Any single health outcome can only provide a particular view of the impact of a disease…
Economic Burden of Rheumatic Diseases
31 Economic Burden of Rheumatic Diseases Edward Yelin Key Points Studies of the economic burden of diseases are especially helpful in allocation of health care resources for musculoskeletal conditions in…
Psychosocial Management of Rheumatic Diseases
67 Psychosocial Management of Rheumatic Diseases W. Neal Roberts, Jr. Key Points Treatment of unrecognized depression is probably the psychosocial intervention with the greatest impact and is frequently required. Matching…
Epigenetics
22 Epigenetics Caroline Ospelt, Steffen Gay Key Points Epigenetic changes have a lasting effect on gene expression by modification of histone tails and DNA. DNA methylation silences gene expression, while…
Cardiovascular Risk in Rheumatic Disease
36 Cardiovascular Risk in Rheumatic Disease Sherine E. Gabriel, Deborah Symmons Key Points For nearly half a century, excess rates of cardiovascular disease (CVD) have been reported among patients with…
Occupational and Recreational Musculoskeletal Disorders
35 Occupational and Recreational Musculoskeletal Disorders Karina D. Torralba, Richard S. Panush Key Points Some occupational and recreational activities have been linked with musculoskeletal syndromes or disorders. These include certain…
Biologic Markers
34 Biologic Markers Jeroen DeGroot, Anne-Marie Zuurmond, Paul-Peter Tak Key Points Uniform definitions of disease are essential for biomarker validation and comparison among studies. The validation process of a biomarker…
Acute Monoarthritis
41 Acute Monoarthritis Max Field Key Points Inflammatory arthritis causes morning stiffness and pain with restricted joint movement. Pain worsening after movement usually indicates mechanical joint pain. Soft tissue disorders…
