119 Hemophilic Arthropathy Katherine S. Upchurch, Doreen B. Brettler Key Points Severe hemophilia, if not aggressively treated, is often complicated by recurrent hemarthrosis. Recurrent hemarthrosis causes chronic arthropathy with overlapping…
101 Metabolic Bone Disease Nancy E. Lane Key Points Osteoporosis is a disease defined by low bone density and deterioration of microarchitecture, which reduces bone strength and increases fracture risk….
110 Lyme Disease Linda K. Bockenstedt Key Points Lyme disease is caused by infection with tick-transmitted spirochetes of the genus Borrelia burgdorferi sensu lato and has a worldwide distribution. Lyme…
24 Prostaglandins, Leukotrienes, and Related Compounds Robert B. Zurier Key Points Eicosanoid biosynthesis is catalyzed by cyclooxygenases and lipoxygenases. Conversion of the endoperoxide intermediate prostaglandin H2 requires activity of specific…
72 Early Synovitis and Early Undifferentiated Arthritis Annette H.M. van der Helm-van Mil, Thomas W.J. Huizinga Key Points Early synovitis refers to synovitis that is detected by physical examination; the…
3 Cartilage and Chondrocytes Mary B. Goldring Key Points Articular cartilage matrix is heterogeneous and contains numerous extracellular matrix (ECM) proteins, of which the large aggregating proteoglycan aggrecan and collagen…
118 Hemochromatosis Gaye Cunnane Key Points Elevated ferritin (>200 µg/L) and transferrin saturation (>45%) in the absence of other causes are useful screening measures for hereditary hemochromatosis (HHC). Genetic testing should…
100 Treatment of Osteoarthritis Carlos J. Lozada Key Points Osteoarthritis (OA) is the most common form of arthritis. Pain is the most common symptom in patients with OA. The management…
114 Viral Arthritis Stanley J. Naides Key Points Acute-onset, symmetric polyarthritis can be caused by viral infection, especially when accompanied by rash. Always take exposure, travel, occupation, and vaccination histories….
65 Antihyperuricemic Agents Ted R. Mikuls Key Points Urate-lowering therapy (ULT) is central to the management of hyperuricemia in gout. The goal of ULT administration in gout is to reduce…
