Epidemiology of Gout
Gout is the most prevalent inflammatory arthritis in men. The findings of several epidemiologic studies from a diverse range of countries suggest that the prevalence of gout has risen over…
Gout and Crystal Arthropathies
Tuhina Neogi, MD, PhD, FRCPC, Editor Gout is now the most common form of inflammatory arthritis in the United States, with a recent resurgence of research interest in its cause and…
Gout and Crystal Arthropathies
Michael H. Weisman, MD, Consulting Editor Dr Tuhina Neogi has put a new face on an ancient disease in this excellent little issue. The epidemiology of gout is a frightening…
Improving Participation in Clinical Trials of Novel Therapies
Clinical trials in many diseases are experiencing more difficulties in achieving sufficient or timely enrollment of participants; anecdotal reports from trials of novel therapies for systemic lupus erythematosus (SLE) seem…
The Kidney Biopsy in Lupus Nephritis
The kidney biopsy is the standard of care for diagnosis of lupus nephritis and remains necessary to ensure accurate diagnosis and guide treatment. Repeat biopsy should be considered when therapy…
Recent Clinical Trials in Lupus Nephritis
Recent clinical trials have provided evidence for the efficacy of low-dose intravenous cyclophosphamide and mycophenolate mofetil as induction treatment for patients with proliferative lupus nephritis in comparative trials with standard-dose…
Post-marketing Experiences with Belimumab in the Treatment of SLE Patients
Belimumab (Benlysta) is a human recombinant monoclonal antibody that targets and inhibits soluble B-lymphocyte stimulator, also known as B-cell activating factor, a proliferation and survival factor for B cells. The…
Systemic Lupus Erythematosus and Malignancies
The systemic lupus erythematosus (SLE) population has a unique cancer risk profile. This article presents the most recent data on risk of cancer in lupus and discusses possible contributing factors….
Pathogenesis and Treatment of Atherosclerosis in Lupus
The prevalence of atherosclerosis (ATH) is higher in patients with systemic lupus erythematosus (SLE) and occurs at an earlier age. The lupus-related factors that account for this increased risk are…
Impact of Race and Ethnicity in the Course and Outcome of Systemic Lupus Erythematosus
Genetic factors seem to play a more important role early in the course of systemic lupus erythematosus (SLE), whereas nongenetic factors seem to play a more important role over the…
