Allergic Rhinitis and Associated Disorders
Allergic Rhinitis and Associated Disorders F. Estelle R. Simons Allergic rhinitis, or inflammation of the nasal mucosa, is the most common chronic disease of the respiratory tract and the most…
Atopic Dermatitis
Atopic Dermatitis Hugh A. Sampson The French physician, Besnier, presented the first comprehensive description of atopic dermatitis over a century ago. He emphasized its hereditary nature, chronically recurring course, and…
Food Allergies
Food Allergies Hugh A. Sampson Adverse food reactions may be divided into toxic and nontoxic reactions. Toxic reactions may occur in anyone, provided a sufficient dose is ingested (e.g., histamine…
Urticaria and Angioedema
Urticaria and Angioedema Thomas B. Casale Jeffrey R. Stokes Urticaria (hives) is characterized by erythematous, edematous wheals of the superficial layers of the skin or mucous membranes. The lesions blanch…
General Considerations of Allergies in Childhood
General Considerations of Allergies in Childhood Hugh A. Sampson Peyton A. Eggleston The prevalence of allergic disorders such as asthma, atopic dermatitis, and allergic rhinitis has doubled in the past…
Unclassified Nervous System Disorders: Alpers Disease
Unclassified Nervous System Disorders: Alpers Disease Marvin A. Fishman The term Alpers disease (progressive poliodystrophy) traditionally has been used to refer to a progressive degenerative disease that begins in early…
Phakomatoses and Other Neurocutaneous Syndromes
Phakomatoses and Other Neurocutaneous Syndromes Sharon E. Plon NEUROFIBROMATOSIS Neurofibromatosis (NF) is the term used for a set of distinct disorders that share some clinical characteristics, with NF types 1…
Diseases with Astrocyte Abnormalities
Diseases with Astrocyte Abnormalities Marvin A. Fishman ALEXANDER DISEASE Alexander disease is a degenerative disorder of the nervous system caused by a mutation in the gene encoding glial fibrillary acidic…
