To make the situation even more complex, aggrecans form aggregates with two other matrix components—hyaluronan and link proteins. This aggregate consists of a variable number of proteoglycan monomers, depending on…
Like members of most families, the collagens share certain similarities but also possess characteristic differences. To date, 28 types of collagen macromolecules have been identified. The most abundant, type I…
In actively growing, or remodeling, trabecular bone, the direction of deposition can be determined by a row of osteoblasts on one border of the trabecula (see Plate 2-23). The deposition…
Cortical bone is remodeled by on the periosteal, endosteal, and haversian canal surfaces. These surfaces are called bone envelopes, or remodeling bays. The periosteal surface is responsible for the growth…
Mature lamellar bone has the same chemical composition and material properties throughout the skeleton, regardless of its mechanism of formation—intramembranous or endochondral—or its structural organization—cortical (compact) or trabecular bone. Skeletal…
The osteoblast, or bone-forming cell, is approximately 20 µm in diameter and contains a single eccentric nucleus. Under the direction of RUNX2 and Osterix transcription factors, osteoblasts arise from osteoprogenitor…
Metaphysis. The three functions of the metaphysis are vascular invasion of the transverse septa at the bottom of the cartilaginous portion of the growth plate, bone formation, and bone remodeling…
Regardless of its specialized function, all cartilage consists of cells—chondrocytes and chondroblasts. These cells synthesize and deposit around them an elaborate matrix of macromolecules that are some of the largest…
Hypertrophic Zone. The functions of this zone are preparation of the matrix for expansion, degradation, and matrix calcification. Chondrocytes in this zone progressively become more spherical and greatly enlarged along…
In glycolysis, glucose-6-phosphate, derived either from the degradative phosphorylation of glycogen or from the phosphorylation of glucose in serum, is broken down into two molecules of acetyl coenzyme A (CoA)….
