Future Directions of Genomics Research in Rheumatic Diseases

Sep 28, 2017 by in RHEUMATOLOGY Comments Off on Future Directions of Genomics Research in Rheumatic Diseases

Recent developments in human genome genotyping and sequencing technologies, such as genome-wide association studies and whole-genome sequencing analyses, have successfully identified several risk genes of rheumatic diseases. Fine-mapping studies using…

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Genetics of Juvenile Idiopathic Arthritis

Sep 28, 2017 by in RHEUMATOLOGY Comments Off on Genetics of Juvenile Idiopathic Arthritis

Juvenile idiopathic arthritis (JIA) affects approximately 1 in 1000 US children. The cause of JIA is most likely multifactorial and due to an interplay of genetics and environmental factors. This…

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Genomics of Systemic Lupus Erythematosus

Sep 28, 2017 by in RHEUMATOLOGY Comments Off on Genomics of Systemic Lupus Erythematosus

Systemic lupus erythematosus (SLE) is a systemic, autoimmune, multisystem disease with a heterogeneous clinical phenotype. Genome-wide association studies have identified multiple susceptibility loci, but these explain a fraction of the…

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Genetics and the Causes of Ankylosing Spondylitis

Sep 28, 2017 by in RHEUMATOLOGY Comments Off on Genetics and the Causes of Ankylosing Spondylitis

Ankylosing spondylitis (AS) is a common inflammatory arthritis in which genetic factors are the primary determinants of disease risk and severity. Substantial progress has been made in identifying genetic pathways…

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Genomic Influences on Hyperuricemia and Gout

Sep 28, 2017 by in RHEUMATOLOGY Comments Off on Genomic Influences on Hyperuricemia and Gout

Genome-wide association studies (GWAS) have identified nearly 30 loci associated with urate concentrations that also influence the subsequent risk of gout. The ABCG2 Q141 K variant is highly likely to be…

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Precision Medicine in Rheumatoid Arthritis

Sep 28, 2017 by in RHEUMATOLOGY Comments Off on Precision Medicine in Rheumatoid Arthritis

Treatment of rheumatoid arthritis (RA) has substantially improved in recent years because of the development of novel drugs. However, response is not universal for any of the treatment options, and…

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