New Treatment Guidelines for Sjögren’s Disease

Sep 28, 2017 by in RHEUMATOLOGY Comments Off on New Treatment Guidelines for Sjögren’s Disease

Sjögren’s disease is associated with a high burden of illness, diminished quality of life, and increased health care costs. The Sjögren’s Syndrome Foundation developed the first US clinical practice guidelines…

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Sjögren Syndrome

Sep 28, 2017 by in RHEUMATOLOGY Comments Off on Sjögren Syndrome

Sjögren syndrome (SS) comprises glandular and extraglandular manifestations. Double-blind prospective trials of traditional disease-modifying antirheumatic drugs and biologics have failed because they have not improved benign symptoms, the major cause…

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Polyautoimmunity in Sjögren Syndrome

Sep 28, 2017 by in RHEUMATOLOGY Comments Off on Polyautoimmunity in Sjögren Syndrome

Polyautoimmunity is defined as the presence of more than one well-defined autoimmune disease (AD) in a single patient. Polyautoimmunity is a frequent condition in Sjögren syndrome (SS) and follows a…

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The Proteomics of Saliva in Sjögren’s Syndrome

Sep 28, 2017 by in RHEUMATOLOGY Comments Off on The Proteomics of Saliva in Sjögren’s Syndrome

One of the main characteristics of primary Sjögren’s syndrome (pSS) is chronic dysfunction and destruction of the salivary and lacrimal glands; their secretory biofluids should reflect the glandular biological status….

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Genetics in Sjögren Syndrome

Sep 28, 2017 by in RHEUMATOLOGY Comments Off on Genetics in Sjögren Syndrome

The genes associated with Sjögren syndrome (SS) can be assigned to the NF-kB pathway, the IFN signaling pathway, lymphocyte signaling, and antigen presentation. The frequencies of risk variants show they…

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Autoantibodies in Sjögren’s Syndrome

Sep 28, 2017 by in RHEUMATOLOGY Comments Off on Autoantibodies in Sjögren’s Syndrome

We compiled information on antibodies in Sjögren syndrome, focusing more on clinical manifestations associated with anti-Ro/SSA and anti-La/SSB antibodies and studies regarding novel antibodies. We reviewed previous as well as…

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Use of Biologics in Sjögren’s Syndrome

Sep 28, 2017 by in RHEUMATOLOGY Comments Off on Use of Biologics in Sjögren’s Syndrome

The management of patients suffering from primary Sjögren syndrome (pSS) has long been mainly symptomatic and demonstration of effectiveness of systemic drugs was lacking. However, progress made in the understanding…

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