Paget’s Disease of Bone
Paget’s Disease of Bone John H. Healey Andrea Piccioli Originally called osteitis deformans, Paget’s disease of bone (PDB) is a disease characterized clinically by inflammatory and mechanical bone/joint pain and…
Osteoporosis
Osteoporosis Alexander Krawiecki Joseph M. Lane Joseph L. Barker KEY POINTS Osteoporosis (OP) is often undertreated and underrecognized. The best way to avoid the complications of OP is to take…
Osteoarthritis
Osteoarthritis John F. Beary III Michael E. Luggen KEY POINTS Osteoarthritis (OA) is the most common musculoskeletal problem in patients older than 50 years, and affects 21 million Americans. OA…
Osteonecrosis
Osteonecrosis John H. Healey Andrea Piccioli Osteonecrosis (ON) is defined as the death in situ of a segment of bone. Avascular necrosis (AVN), aseptic necrosis, and bone infarction are terms…
Rheumatic Fever
Rheumatic Fever Allan Gibofsky John B. Zabriskie KEY POINTS Acute rheumatic fever (ARF) is a systemic rheumatic disease that occurs in a genetically susceptible individual following streptococcal pharyngitis. The streptococcal…
Whipple’s Disease
Whipple’s Disease Stephen A. Paget Kristina Belostocki KEY POINTS Whipple’s disease (WD) is a rare multisystem syndrome caused by the gram-positive actinomycete Tropheryma whippelii. The clinical manifestations of WD include…
Osteomyelitis
Osteomyelitis Juliet Aizer Barry D. Brause KEY POINTS The diagnosis of osteomyelitis is dependent upon understanding the pathogenetic mechanisms involved in the three routes of infection: hematogenous osteomyelitis, introduced infection,…
Lyme Disease
Lyme Disease Anne R. Bass Steven K. Magid KEY POINTS Lyme disease is caused by the spirochete Borrelia burgdorferi. In endemic areas, B. burgdorferi is transmitted by the bite of…
Infectious Arthritis
Infectious Arthritis Barry D. Brause Juliet Aizer KEY POINTS Septic arthritis should be diagnosed and appropriately treated with urgency to reduce the risk of permanent loss of joint function. The…
Human Immunodeficiency Virus
Human Immunodeficiency Virus Edward Parrish INTRODUCTION A number of musculoskeletal complaints and inflammatory phenomena develop in individuals infected with the human immunodeficiency virus (HIV). These patients are exposed to a…
