Why is osteoarthritis an age-related disease?
Although older age is the greatest risk factor for osteoarthritis (OA), OA is not an inevitable consequence of growing old. Radiographic changes of OA, particularly osteophytes, are common in the…
Developing a minimum standard of care for treating people with osteoarthritis of the hip and knee
We reviewed three recently published guidelines for the management of osteoarthritis (OA) and considered the evidence and potential for implementation. From this we propose a minimum standard of care, or…
Targeted therapies in osteoarthritis: a systematic review of the trials on www.clinicaltrials.gov
A systematic review of the clinical trials in osteoarthritis registered on the public website of the Clinical Trials Data Bank at the National Institutes of Health (NIH) has been performed….
Non-pharmacological approaches for the treatment of osteoarthritis
For the most part, non-pharmacological approaches are recommended for osteoarthritis treatment. This recommendation is based mainly on biomechanical observations leading to a modulation of the symptomatic loading joint. Approaches include…
Targeting the synovial tissue for treating osteoarthritis (OA): where is the evidence?
Osteoarthritis (OA) is often a progressive and disabling disease, which occurs in the setting of a variety of risk factors – such as advancing age, obesity and trauma – that…
What are the best markers for disease progression in osteoarthritis (OA)?
To be able to prevent progression of osteoarthritis, the knowledge of prognostic factors of this progression is important. If certain prognostic factors are modifiable, they may enhance our ability to…
Targeting subchondral bone for treating osteoarthritis: what is the evidence?
Over the past few decades, significant progress has been made with respect to new concepts about the pathogenesis of osteoarthritis (OA). This article summarises some of the knowledge we have…
The role of biomechanics in the initiation and progression of OA of the knee
The knee is one of the most common joints affected by osteoarthritis (OA), frequently with clinical presentation by middle age or even earlier. Accumulating evidence supports that knee OA progression…
Arthroscopy as a treatment for knee osteoarthritis
Since surfaces become irregular and debris from cartilage and meniscus gets released into the joint cavity of osteoarthritic joints, washing away this debris and attendant crystals, smoothing rough surfaces and…
Imaging the joint in osteoarthritis: a place for ultrasound?
Ultrasound (US) is a valuable tool for imaging musculoskeletal changes in osteoarthritis. It shows early and late findings related to inflammation and structural damage. Sonography is a safe tool, which…
