Paraneoplastic Musculoskeletal Syndromes and Hypertrophic Osteoarthropathy Alan T. Kaell INTRODUCTION If a close temporal relation exists between the discovery of a malignancy and the onset of a rheumatic syndrome, an…
Fibromyalgia and Chronic Pain Daniel J. Clauw John F. Beary III KEY POINTS Fibromyalgia (FM) is a painful, noninflammatory condition characterized by a history of widespread pain, and diffuse tenderness…
Endocrine Arthropathies Michael D. LockshinH KEY POINTS The musculoskeletal manifestations of endocrine diseases include muscle dysfunction, disorders of bone metabolism, and cartilage deformation. Endocrinopathic musculoskeletal disease tends to be diffuse…
Paget’s Disease of Bone John H. Healey Andrea Piccioli Originally called osteitis deformans, Paget’s disease of bone (PDB) is a disease characterized clinically by inflammatory and mechanical bone/joint pain and…
Osteoporosis Alexander Krawiecki Joseph M. Lane Joseph L. Barker KEY POINTS Osteoporosis (OP) is often undertreated and underrecognized. The best way to avoid the complications of OP is to take…
Osteoarthritis John F. Beary III Michael E. Luggen KEY POINTS Osteoarthritis (OA) is the most common musculoskeletal problem in patients older than 50 years, and affects 21 million Americans. OA…
Osteonecrosis John H. Healey Andrea Piccioli Osteonecrosis (ON) is defined as the death in situ of a segment of bone. Avascular necrosis (AVN), aseptic necrosis, and bone infarction are terms…
Rheumatic Fever Allan Gibofsky John B. Zabriskie KEY POINTS Acute rheumatic fever (ARF) is a systemic rheumatic disease that occurs in a genetically susceptible individual following streptococcal pharyngitis. The streptococcal…
Whipple’s Disease Stephen A. Paget Kristina Belostocki KEY POINTS Whipple’s disease (WD) is a rare multisystem syndrome caused by the gram-positive actinomycete Tropheryma whippelii. The clinical manifestations of WD include…
Osteomyelitis Juliet Aizer Barry D. Brause KEY POINTS The diagnosis of osteomyelitis is dependent upon understanding the pathogenetic mechanisms involved in the three routes of infection: hematogenous osteomyelitis, introduced infection,…
