Genetics in Sjögren Syndrome
The genes associated with Sjögren syndrome (SS) can be assigned to the NF-kB pathway, the IFN signaling pathway, lymphocyte signaling, and antigen presentation. The frequencies of risk variants show they…
RHEUMATOLOGY
Autoantibodies in Sjögren’s Syndrome
We compiled information on antibodies in Sjögren syndrome, focusing more on clinical manifestations associated with anti-Ro/SSA and anti-La/SSB antibodies and studies regarding novel antibodies. We reviewed previous as well as…
Use of Biologics in Sjögren’s Syndrome
The management of patients suffering from primary Sjögren syndrome (pSS) has long been mainly symptomatic and demonstration of effectiveness of systemic drugs was lacking. However, progress made in the understanding…
Sjögren Syndrome in the Twenty-First Century
R. Hal Scofield, MD, Editor Sjögren syndrome is a chronic, systemic autoimmune disease that is common and has important life-altering and severe effects on those with the disease. Despite these facts, the…
Sjogren’s Disease
Michael H. Weisman, MD, Consulting Editor Hal Scofield has done a remarkable job in assembling a timely, up-to-date, and thoughtful review of Sjogren syndrome (SS). It does appear that the…
Imaging of Musculoskeletal Infection
Diagnostic imaging plays a crucial role in confirming the diagnosis of musculoskeletal (MSK) infection and determining the severity and extent of disease. The clinical diagnosis may be challenging due to…
Synovial Tumors and Proliferative Diseases
The clinical diagnosis of synovial tumors and synovial proliferative processes is difficult, as symptoms and physical examination findings are often nonspecific. Advanced imaging modalities, such as MRI, high-resolution ultrasound, and…
The Expanding Role of Imaging in Systemic Vasculitis
Various imaging modalities, including color duplex ultrasonography, CT angiography, magnetic resonance angiography, and PET, are emerging as important aids to the diagnosis, staging, evaluation of disease activity and response to…
Current Perspectives on Imaging for Systemic Lupus Erythematosus, Systemic Sclerosis, and Dermatomyositis/Polymyositis
Systemic rheumatic diseases frequently pose diagnostic challenges to the clinician. The precise nature of the disorder can be obscure and different disorders can present with similar symptoms, such as joint…
Imaging for Synovitis, Acne, Pustulosis, Hyperostosis, and Osteitis (SAPHO) Syndrome
Multifocal osteomyelitis and synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) syndrome constitute a spectrum of disease that includes inflammatory bone lesions and dermatologic findings. Radiographic features resemble those of the…
