Vitamin D: Metabolism
The biologically active metabolite of vitamin D, 1,25(OH) 2 D 3 , affects mineral homeostasis and has numerous other diverse physiologic functions including effects on growth of cancer cells and…
RHEUMATOLOGY
Epilogue: How Will We Care for Patients with Early Arthritis?
This article draws conclusions about pinpointing the actual onset of disease and when interventions should start to occur. The identification of necessary biomarkers will be discussed. We will also examine…
Environmental and Gene-Environment Interactions and Risk of Rheumatoid Arthritis
Multiple environmental factors including hormones, dietary factors, infections, and exposure to tobacco smoke, as well as gene-environment interactions, have been associated with increased risk for rheumatoid arthritis (RA). The growing…
Early Psoriatic Arthritis
Psoriatic arthritis is an inflammatory musculoskeletal disease associated with psoriasis that is usually seronegative for rheumatoid factor. Psoriatic arthritis affects men and women equally, usually during the fourth decade, although…
Early Juvenile Idiopathic Arthritis
Early juvenile idiopathic arthritis (JIA) is important to recognize as timely diagnosis and treatment improves prognosis. It is a misconception that complications of JIA arise only from long-standing disease and…
Early Spondyloarthritis
Spondyloarthritis (SpA) is a large family of chronic inflammatory diseases characterized by inflammation of the axial skeleton, a typically asymmetric peripheral arthritis of the lower limbs, enthesitis, typical extra-articular manifestations,…
Magnetic Resonance Imaging Applications in Early Rheumatoid Arthritis Diagnosis and Management
Early diagnosis and treatment have been recognized as essential for improving clinical outcomes in patients with rheumatoid arthritis (RA). Magnetic resonance imaging (MRI) is a sensitive modality that can assess…
Evolution of Classification Criteria for Rheumatoid Arthritis: How Do the 2010 Criteria Perform?
Classification criteria are created in an attempt to produce a homogenous group of subjects with rheumatoid arthritis (RA) who can be used for clinical and basic research. The 1987 revised…
Tight Disease Control in Early RA
The past decade has brought increasing evidence to support aggressive therapeutic intervention in early rheumatoid arthritis (RA). Treat-to-target strategies that focus on frequent monitoring and treatment adjustments to achieve states…
Initial Management of Rheumatoid Arthritis
The prognosis for the patient with newly diagnosed rheumatoid arthritis (RA) has dramatically changed over the last two decades. If a patient is diagnosed and treated early by a rheumatologist…
