General Features of Osteoarthritis
General Features of Osteoarthritis What are the clinical features of osteoarthritis? The clinical features of osteoarthritis relate to both symptoms and signs. As has been discussed in Chapter 1, the…
ORTHOPEDIC
Management of Osteoporosis
Management of Osteoporosis Introduction Bone loss with ageing is universal and many will become osteoporotic in later life with increased risk of fracture. Measures therefore need to be taken by…
Future Therapeutic Options
Future Therapeutic Options Paul D. Miller Current osteoporosis therapies have been shown to reduce the risk of fragility fractures generally from 50% to 65% over a period of 3 years….
Clinical Cases
Clinical Cases Pauline M. Camacho Paul D. Miller Case 1 History A 61-year-old white woman had a dual-energy x-ray absorptiometry (DXA) scan ordered by her primary-care physician. Other than mild…
Tailoring Therapy to Individual Patients
Tailoring Therapy to Individual Patients Paul D. Miller The pharmacological agents for the prevention and treatment of postmenopausal osteoporosis (PMO) registered with the Food and Drug Administration (FDA) are listed…
Determining Success of Therapy and What to Do When Therapy Fails
Determining Success of Therapy and What to Do When Therapy Fails Paul D. Miller Osteoporosis therapies are designed to improve bone strength and reduce the risk for fracture. When the…
Treatment Options
Treatment Options Pauline M. Camacho The National Osteoporosis Foundation has outlined clinical recommendations regarding initiation of therapy for low bone mass and osteoporosis (Table 8.1). According to their guidelines, treatment…
Acquired Vitamin D Deficiency
Acquired Vitamin D Deficiency Pauline M. Camacho Epidemiology This chapter focuses on acquired vitamin D deficiency among adults. The prevalence of this condition has been reported to be as high…
Secondary Causes of Osteoporosis*
Secondary Causes of Osteoporosis* Pauline M. Camacho Current therapies for osteoporosis are efficacious in reducing fractures and improving surrogate markers [i.e., bone mineral density (BMD) and bone markers]. Correctable factors…
Biochemical Evaluation
Biochemical Evaluation Pauline M. Camacho Successful management of osteoporosis requires a careful choice of biochemical tests to determine the presence of secondary causes of osteoporosis. In addition, biochemical markers of…
