Polyautoimmunity in Sjögren Syndrome
Polyautoimmunity is defined as the presence of more than one well-defined autoimmune disease (AD) in a single patient. Polyautoimmunity is a frequent condition in Sjögren syndrome (SS) and follows a…
The Proteomics of Saliva in Sjögren’s Syndrome
One of the main characteristics of primary Sjögren’s syndrome (pSS) is chronic dysfunction and destruction of the salivary and lacrimal glands; their secretory biofluids should reflect the glandular biological status….
Genetics in Sjögren Syndrome
The genes associated with Sjögren syndrome (SS) can be assigned to the NF-kB pathway, the IFN signaling pathway, lymphocyte signaling, and antigen presentation. The frequencies of risk variants show they…
Autoantibodies in Sjögren’s Syndrome
We compiled information on antibodies in Sjögren syndrome, focusing more on clinical manifestations associated with anti-Ro/SSA and anti-La/SSB antibodies and studies regarding novel antibodies. We reviewed previous as well as…
Use of Biologics in Sjögren’s Syndrome
The management of patients suffering from primary Sjögren syndrome (pSS) has long been mainly symptomatic and demonstration of effectiveness of systemic drugs was lacking. However, progress made in the understanding…
Sjögren Syndrome in the Twenty-First Century
R. Hal Scofield, MD, Editor Sjögren syndrome is a chronic, systemic autoimmune disease that is common and has important life-altering and severe effects on those with the disease. Despite these facts, the…
Sjogren’s Disease
Michael H. Weisman, MD, Consulting Editor Hal Scofield has done a remarkable job in assembling a timely, up-to-date, and thoughtful review of Sjogren syndrome (SS). It does appear that the…
Imaging of Musculoskeletal Infection
Diagnostic imaging plays a crucial role in confirming the diagnosis of musculoskeletal (MSK) infection and determining the severity and extent of disease. The clinical diagnosis may be challenging due to…
Synovial Tumors and Proliferative Diseases
The clinical diagnosis of synovial tumors and synovial proliferative processes is difficult, as symptoms and physical examination findings are often nonspecific. Advanced imaging modalities, such as MRI, high-resolution ultrasound, and…
The Expanding Role of Imaging in Systemic Vasculitis
Various imaging modalities, including color duplex ultrasonography, CT angiography, magnetic resonance angiography, and PET, are emerging as important aids to the diagnosis, staging, evaluation of disease activity and response to…
