Systemic Lupus Erythematosus and Malignancies
The systemic lupus erythematosus (SLE) population has a unique cancer risk profile. This article presents the most recent data on risk of cancer in lupus and discusses possible contributing factors….
Pathogenesis and Treatment of Atherosclerosis in Lupus
The prevalence of atherosclerosis (ATH) is higher in patients with systemic lupus erythematosus (SLE) and occurs at an earlier age. The lupus-related factors that account for this increased risk are…
Impact of Race and Ethnicity in the Course and Outcome of Systemic Lupus Erythematosus
Genetic factors seem to play a more important role early in the course of systemic lupus erythematosus (SLE), whereas nongenetic factors seem to play a more important role over the…
The Immunopathology of Cutaneous Lupus Erythematosus
Systemic lupus erythematosus (SLE) is an autoimmune disease that is characterized by the development of autoantibodies and immunologic attack of different organ systems, including the skin. This review aims to…
Clinical Perspectives on Lupus Genetics
In recent years, genome-wide association studies have led to an expansion in the identification of regions containing confirmed genetic risk variants within complex human diseases, such as systemic lupus erythematosus…
Environmental Influences on Systemic Lupus Erythematosus Expression
The etiology of systemic lupus erythematosus (SLE) is unknown, but multiple genetic, epigenetic, and environmental risk factors have been implicated. The inheritance of genes alone is not sufficient for developing…
Systemic Lupus Erythematosus
Ellen M. Ginzler, MD, MPH, Editor Mary Anne Dooley, MD, MPH, Editor The last issue of Rheumatic Disease Clinics of North America to cover systemic lupus erythematosus (SLE) was published…
Lessons from Type 1 Diabetes for Understanding Natural History and Prevention of Autoimmune Disease
Type 1 diabetes (T1D) is a chronic autoimmune disorder resulting from immune-mediated destruction of insulin-producing beta cells within the pancreatic islets. Prediction of T1D is now possible, as having 2…
Developing Evidence-Based Screening Recommendations, with Consideration for Rheumatology
Screening for presymptomatic disease provides the potential for early intervention and improved outcomes. However, although this practice has potential benefits, it also has potential harms that must be considered. The…
Prediction of Future Rheumatoid Arthritis
Rheumatoid arthritis (RA) results from an interaction between genetic susceptibility and environmental factors. Several of these factors are known, such as family history of RA, high birth weight, smoking, silica…
