Spondyloarthritis (SpA) represents a group of interrelated diseases with common clinical features and a close association with HLA-B27. Reports of incidence and prevalence of diseases vary depending on methodological differences…
Systemic lupus erythematosus (SLE) is the prototypic autoimmune disease with diverse clinical manifestations, affecting virtually all organ systems. A wide variety of medications are used for treatment, depending on organ involvement…
The burden of comorbid diseases is high among patients with rheumatoid arthritis (RA). These are often systemic manifestations of RA but may be chronic conditions that predate or develop post-RA…
The management of rheumatoid arthritis (RA) dramatically changed in 1998 with the introduction of etanercept and infliximab for the treatment of RA and Crohn colitis. Nine biologic agents are currently…
The expansion of therapeutic options for rheumatoid arthritis (RA) has improved the functional, quality of life, and radiographic outcomes for patients, although immunomodulatory and immunosuppressive effects may increase the potential…
Patients with rheumatoid arthritis are at higher risk for serious infections and death from infection than the general public. Prednisone and biologic agents increase this risk, although the risk associated…
Nonserious infections (NSIE) as colds, flu syndromes, and urinary tract infection, are the most common infections seen in patients with immune mediated inflammatory diseases. Yet, little is known about the…
Bisphosphonates are antiresorptive medications widely prescribed for treating osteoporosis. In placebo-controlled clinical trials they have been shown to significantly reduce the risk of osteoporotic fractures. However, reports of atypical femoral…
When proposing a new therapy, rheumatologists must inform patients of a range of therapeutic options and support them towards making an informed decision. This article introduces definitions of equipoise and…
Gout is a metabolic disorder of purine metabolism and uric acid elimination. Over time, acute gout can develop into a chronic, disabling arthropathy, often associated with multiple comorbidities. Gout patients…
