Bisphosphonates are antiresorptive medications widely prescribed for treating osteoporosis. In placebo-controlled clinical trials they have been shown to significantly reduce the risk of osteoporotic fractures. However, reports of atypical femoral…
When proposing a new therapy, rheumatologists must inform patients of a range of therapeutic options and support them towards making an informed decision. This article introduces definitions of equipoise and…
Gout is a metabolic disorder of purine metabolism and uric acid elimination. Over time, acute gout can develop into a chronic, disabling arthropathy, often associated with multiple comorbidities. Gout patients…
John J. Cush, MD, Guest Editor Kathryn H. Dao, MD, Guest Editor An exciting era of rheumatology is upon us. Advances in pathobiology have produced novel advances in the treatment…
The most favorable mechanical environment for the hip is one that is free of both instability and impingement, creating a concentric articulation with optimum femoral head coverage by the acetabulum….
International evidence-based guidelines recommend a multitude of nonsurgical treatment options for the management of osteoarthritis. This article summarizes the evidence available for patient characteristics that have been analyzed as potential…
Osteoarthritis (OA) is a significant and growing concern to a large segment of the population. Effective treatments for slowing or stopping the progression of the disease are not available despite…
Although total knee replacement is an excellent treatment of end-stage osteoarthritis of the knee in the older (>65 years) population, many patients with less severe disease are significantly impacted by…
This updated review outlines the influence of muscle activity on knee joint loading, describes the deficits in muscle function observed in people with knee osteoarthritis, and summarizes available evidence pertaining…
Osteoarthritis is the most prevalent chronic joint disease worldwide. The incidence and prevalence are increasing as the population ages and lifestyle risk factors such as obesity increase. There are several…
