Bone tumors can simulate a wide range of rheumatic disorders, delaying tumor diagnosis and therefore the probability of cure. This review describes the clinical presentation of primary and metastatic bone…
Malignant disease often needs to be considered in the initial evaluation of patients with synovitis. Cancer can affect the synovium directly, either as a primary tumor or as a metastasis….
Autoantibodies are extremely promising diagnostic and prognostic biomarkers of cancer, and have the potential to promote early diagnosis and to make a large impact by improving patient outcome and decreasing…
The wide range of rheumatic and musculoskeletal conditions that can appear in association with cancer emphasizes that rheumatic disease is a major component of the spectrum of paraneoplastic manifestations. Although the…
Kenneth J. Scalapino, MD, Guest Editor Charles R. Thomas Jr, MD, Guest Editor Neoplastic diseases are characterized by a diversity of structural, hematologic, metabolic, immunologic, and biochemical abnormalities producing a…
Vitamin D has gone through a renaissance with the association of vitamin D deficiency with a wide array of common diseases including breast, colorectal and prostate cancers, cardio-vascular disease, autoimmune…
Type 1 (T1D) and type 2 (T2D) diabetes are considered multifactorial diseases in which both genetic predisposition and environmental factors participate in their development. Many cellular, preclinical, and observational studies…
Calcitriol (1,25-dihydroxyvitamin D 3 ), the hormonally active form of vitamin D, exerts growth inhibitory and prodifferentiating effects on many malignant cells and retards tumor growth in animal models. Calcitriol…
Vitamin D deficiency is the most common nutritional deficiency and likely the most common medical condition in the world. The major cause of vitamin D deficiency has been the lack…
Interaction with the immune system is one of the most well-established nonclassic effects of vitamin D. For many years this was considered to be a manifestation of granulomatous diseases such…
