Plain Radiography and Advanced Imaging of Gout
Key Points • Radiography is the main imaging modality for evaluation of progression of gout, but there is a 5- to 10-year latent period between first clinical symptoms and the…
Ultrasound in the Diagnosis of Crystal Deposition Disease
Key Points • Assessment of nephrolithiasis, cholecystolithiasis, and ureteral calcified concrements has been the main indication for ultrasound in internal medicine. Ultrasound can detect uric acid–containing kidney stones that would…
Epilogue: Creating a Better Future of Diagnosis and Treatment of Gout and Other Crystal Arthropathies
Supported by the VA Research Service. Introduction This textbook has thoroughly covered the current status of gout clinical practice, a subject whose nuances, with respect to evidence-based medicine, have been…
Basic Calcium Phosphate Crystal Arthropathy
Key Points • Basic calcium phosphate (BCP) crystals are a group of ultramicroscopic crystals that are mainly composed of hydroxyapatite and are frequently deposited in articular tissues. • BCP crystal…
Crystalline Disorders Associated With Renal Disease Including Oxalate Arthropathy
Key Points • Rheumatic syndromes are a common complication of chronic kidney disease (CKD); regardless of renal disease etiology, musculoskeletal symptoms have been reported in up to 82% of patients…
Calcium Pyrophosphate Dihydrate Crystal Deposition: Epidemiology, Clinical Features, Diagnosis, and Treatment
Key Points • Calcium pyrophosphate dihydrate (CPPD) crystal deposition is a metabolic disorder that manifests substantially more often as joint pathology than it does as a symptomatic arthropathy. • The…
Asymptomatic Hyperuricemia: Cardiovascular and Renal Implications
Key Points • There are a number of in vitro and in vivo models supporting a complex potential relation of hyperuricemia to both cardiovascular and renal outcomes. • Definitive evidence…
Pathogenesis and Molecular Genetics of Calcium Pyrophosphate Dihydrate Crystal Deposition Disease
Key Points • By far the majority of calcium pyrophosphate dihydrate (CPPD) crystal deposition disease is an idiopathic/sporadic disease with onset in later life, but early-onset familial disease also occurs….
Health-Related Quality of Life and Outcome Measures in Gout
Key Points • Despite the growing prevalence of gout, only a few studies have examined the overall impact of gout on patient’s health-related quality of life (HRQOL). HRQOL refers to…
Uricase Therapy of Gout
Key Points • Uricolytic therapy with uricase (urate oxidase) degrades uric acid, ultimately resulting in the production of allantoin, which is much more soluble and readily excreted in the urine…
