Musculoskeletal Key

CLINICAL SUMMARY Multiple myeloma presents as a proliferation of plasma cells in the marrow and is the most common primary malignancy of bone. Like other round cell tumors, myeloma lesions…

CLINICAL SUMMARY The lymphoid malignancies are a large and heterogeneous group. Bone involvement is usually a manifestation of late, disseminated disease, although bone infrequently can be the primary site. In…

CLINICAL SUMMARY Aneurysmal bone cysts (ABCs) derive their name from their radiologic appearance and therefore do not represent a single pathologic entity. Although many ABCs are actually secondary features of…

CLINICAL SUMMARY Elastofibroma is a slow-growing, reactive lesion that is found almost exclusively between the scapula and chest wall. These lesions are more frequent in older patients and are common…

CLINICAL SUMMARY Ewing sarcoma is approximately half as common as osteosarcoma. It arises from bone marrow and almost always presents with a large soft tissue mass. Compared to osteosarcoma, it…

CLINICAL SUMMARY Giant cell tumor of bone is a benign but destructive bone tumor that is usually discovered adjacent to the knee joint in young adults. Although curettage is the…

CLINICAL SUMMARY Chordoma is a slow-growing malignancy with a strong predisposition for the sacrum and skull base. Because of its location, sacrococcygeal chordoma is often discovered after it has attained…

CLINICAL SUMMARY Osteoid osteomas are small, painful, bone lesions that are typically intracortical. Patients usually present with rest pain as well as night pain. Lesions are easily located with nuclear…

CLINICAL SUMMARY Fibrous dysplasia results when fibrous tissue and metaplastic bone replace marrow and lamellar bone. It is typically an asymptomatic, incidental discovery; however, when a large segment of a…

CLINICAL SUMMARY Adamantinoma is a low-grade malignancy that is found almost exclusively in the tibia and fibula of young adults. Histologically, it is distinguished from other bone tumors by the…