Supported by the VA Research Service. Introduction This textbook has thoroughly covered the current status of gout clinical practice, a subject whose nuances, with respect to evidence-based medicine, have been…
Key Points • Basic calcium phosphate (BCP) crystals are a group of ultramicroscopic crystals that are mainly composed of hydroxyapatite and are frequently deposited in articular tissues. • BCP crystal…
Key Points • Rheumatic syndromes are a common complication of chronic kidney disease (CKD); regardless of renal disease etiology, musculoskeletal symptoms have been reported in up to 82% of patients…
Key Points • Calcium pyrophosphate dihydrate (CPPD) crystal deposition is a metabolic disorder that manifests substantially more often as joint pathology than it does as a symptomatic arthropathy. • The…
Key Points • There are a number of in vitro and in vivo models supporting a complex potential relation of hyperuricemia to both cardiovascular and renal outcomes. • Definitive evidence…
Key Points • By far the majority of calcium pyrophosphate dihydrate (CPPD) crystal deposition disease is an idiopathic/sporadic disease with onset in later life, but early-onset familial disease also occurs….
Key Points • Despite the growing prevalence of gout, only a few studies have examined the overall impact of gout on patient’s health-related quality of life (HRQOL). HRQOL refers to…
Key Points • Uricolytic therapy with uricase (urate oxidase) degrades uric acid, ultimately resulting in the production of allantoin, which is much more soluble and readily excreted in the urine…
Key Points • Gout attacks (also called “flares”) are commonly precipitated by factors that induce rapid rise (e.g., diet and alcohol excess, intensive diuresis for congestive heart failure) or decline…
Key Points • Comprehensive management of gout involves identifying and addressing comorbid cause(s) of the hyperuricemia, treating and preventing attacks of gouty inflammation, and lowering serum urate to an appropriate…
