Reporting DXA Results for Children and Adolescents


I. Patient & provider information
 
Patient name
 
Medical record number
 
Date of birth
 
Gender

Ethnicity/race

Referring physician/provider
 
Measured weight, height (specify units: kg/Ib; cm/in)
 
Calculated BMI, height, weight %, or Zscores
 
Primary diagnosis, indications for DXA test
 
List of current relevant medications
 
Bone age or pubertal stage
 
Inclusion of possible risk factors, including documentation of nontraumatic fractures, sports participation
 
Calcium intake or use of calcium supplements

Use of vitamin D supplements

25OH vitamin D laboratory value

II. Test results
 
Skeletal sites scanned
 
aBMD, BMC, bone area for each site
 
aBMD Zscores for each site by chronological age
 
BMD Z-scores for each site by bone age (if available)

BMD Z-scores for each site adjusted for HAZ (as needed)

III. Technical comments
 
Manufacturer, model of instrument used
 
Software version ( e.g. Hologic Apex 5.3.1)
 
Technical quality of the scans obtained
 
Limitations of the study (e.g., artifacts, scoliosis)
 
Pediatric reference source(s) used for Z -score calculation

IV. Interpretation & recommendations
 
Qualitative assessment of aBMD Z -score results
 
Assessment of calcium intake in reference to DRI

Adjustments made for body size, bone age, pubertal delay

Recommendations for necessity and timing of follow-up DXA scan studies

V. Body composition componentsa
 
Body mass index, kg/m 2

Total mass, with head, g

Total lean mass, g

Total fat mass, g

Percentage fat mass (%)

VI. VFA vertebral fracture assessment componentsb
 
Visual evaluation documentation of vertebral height abnormalities

Fracture diagnosis including type (wedge, biconcave, crush)

Severity (mild, moderate, severe) and grade (1, 2 or 3) of abnormality


The components in plain font are considered standard at most densitometry centers. Those in italics are provided as suggestions

What should NOT be included: aBMD T-scores, and terms “Osteopenia” & “Osteoporosis” based on the results from the DXA examination alone

Semi-quantitative VFA criteria by Genant- Ref. [24] Genant H, et al. JBMR 1993:1137–1148

Modified from

Reference [2]: Crabtree NJ et al. J Clin Densitom 2014;17:2:225–242

a Reference [4]: Petak S et al. J Clin Densitom 2013 16;4:508

b Reference [5]: Vokes T et al. J Clin Densitom 2006;9:1:37




Table 7.2
Additional Components of the Follow-Up DXA Report







































I. Patient & provider information
 
Indication for follow-up DXA scan
 
Interval fractures, change in clinical status, medications

II. Test results
 
Skeletal sites scanned
 
BMD, BMC, bone area for each site
 
Annualized change in BMC, BMD
 
Change in BMD Z-scores

III. Technical comments
 
Which previous scans are being used for comparison?
 
Statement regarding what denotes statistical significance for change in BMD at the center, or LSC
 
Recommendation for necessity and timing of follow-up DXA scan


The elements in plain font are considered standard at most densitometry centers. Those in italics are provided as suggestions

Modified from

Reference [2], Crabtree NJ, et al. J Clin Densitom 2014;17:2:225–242



Patient Demographics


The optimal report includes basic patient demographics (i.e., age, gender, and ethnicity or race) and anthropometrics. Weight and height taken at the time of the DXA scan should always be included in the report, along with their respective units (kg/lb or cm/in). It is very important to document patient height and weight since DXA measures areal, and not true volumetric, bone mineral density. As discussed previously in Chap. 6, bone density is underestimated in small patients as a result of the two-dimensional nature of the instrumentation [8, 9]. Documentation of patient size will be important for interpretation of the scans during the evaluation phase.

Body mass index (kg/m2), growth percentiles, and standard deviation Z-scores should be calculated using current growth charts. The WHO (between 1997 and 2003) completed the Multi-Center Growth Reference Study in 8500 children measured in six countries (Brazil, Ghana, India, Norway, Oman, USA). The new international growth charts (children 0–5 years) have now been adopted for use in many countries in that they represent optimal growth with no nutritional failure. In the United States and Australia, growth charts for older children include those developed by the Centers for Disease Control in 2002 [10], whereas in the United Kingdom, growth charts were recently updated (January, 2013) to combine both UK-WHO data and UK90 now simply: UK Growth Chart [11]. Examples of these growth charts are provided in Appendix B.

The demographic and anthropometric data are helpful in determining if body size is sufficiently above or below the expected range to warrant adjustment of DXA results. For those with short stature or growth delay, the ISCD recommends the use of either Bone Mineral Apparent Density (BMAD) , an estimate of volumetric BMD, or Height for age Z-score (HAZ) calculations to adjust the spine aBMD; HAZ is recommended to adjust the whole body scans [2]. Unfortunately, there are no published pediatric norms to calculate Z-scores from BMAD adjustments. Therefore, aBMD Z-scores are available only for HAZ adjustments [12]. Explanation of the modifications being made should be part of the interpretation section of the DXA report.


Medical History


The report should include a brief summary of the relevant clinical history. This might include the primary medical diagnosis, the use of medications known to affect aBMD (e.g., growth hormone, certain anti-convulsants, glucocorticoids, proton pump inhibitors), fracture history, mobility status, endocrine abnormalities, pubertal status, bone age, and family history of osteoporosis. Physical activity level, dietary history, and use of vitamin or mineral supplements may also be useful.

As discussed in Chap. 5, clinical information prior to the scan improves both the acquisition and the interpretation of bone densitometry. Ideally, the patient’s medical history should be obtained directly from the referring physician. This type of information is typically gathered with a Referral or Request for Procedure form. However, some patients will be referred for bone densitometry assessment without a complete medical history.

If the referring physician has not relayed the indications for the scan and the relevant medical history, it is possible to ask the patient, parent, or both for relevant medical information. At most imaging centers, patients are asked to complete a brief registration questionnaire at the time of the DXA procedure. Examples of pediatric DXA registration questionnaires and request for procedure forms are provided in Appendix D (see also Figure 7.1).

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Fig. 7.1
Example Registration Questionnaire for ‘Patient AB’

The DXA technologist should review the questionnaire with the parent, giving particular attention to details surrounding fracture history, endocrine or growth abnormalities, orthopedic surgeries, medication and supplement usage, and family history of osteoporosis. If, for some reason, the questionnaire cannot be adequately completed at the time of examination (e.g., because of a language barrier or because the child is not accompanied by a parent) , the form can be faxed to the referring clinic for completion after the DXA procedure is completed.


Test Results


For each skeletal site that is assessed, aBMD, BMC, and bone area should be included, as should the corresponding aBMD Z-score, to allow the clinician to determine if the measured values are within the expected range for age. BMC and bone areas are used to calculate estimates of volumetric BMD at the spine [BMAD] and should be included in the report. Reporting BMC and bone area also allows the clinician to examine subsequent changes due to bone growth.

Calculating changes in aBMD over time requires thoughtful consideration in pediatric patients. Although no one approach has been shown to be best, some practices can minimize error. Prior to any calculations or interpretations, scan images should be carefully examined during scan acquisition to optimize comparability of repeated measurements. Many experts believe that it is more informative to examine changes in BMC, rather than aBMD, in pediatric patients because of the variable of growth (see more detail in Chap. 6: Evaluation) [13]. In adult patients, the size of the skeleton remains relatively constant, making longitudinal comparisons of aBMD appropriate. In pediatric patients, bone growth leads to changes in bone area as well as BMC. These parameters may not increase in parallel. In fact, Bailey et al. [14] have shown that peak height velocity precedes the periods of peak bone mineral accrual by several months in teens. In recent years, there are more robust pediatric-specific reference data. However, BMC Z-scores are infrequently reported because they have yet to be incorporated into the manufacturer software. For this reason, the aBMD Z-score is typically reported and, as needed, adjusted for bone and body size.

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Jul 31, 2017 | Posted by in ORTHOPEDIC | Comments Off on Reporting DXA Results for Children and Adolescents

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