Update on Juvenile Spondyloarthritis




Spondyloarthritis (SpA) encompasses a group of disorders linked by overlapping clinical manifestations and genetic predisposition. Newer classification systems developed for adults with SpA focus on identifying individuals with axial or predominantly peripheral involvement. All forms of SpA can begin during childhood, and can be considered on a continuum with adult disease. Nevertheless, there are important differences in presentation and outcome that depend on age at onset. This article highlights these differences, what has been learned about genetics and pathogenesis of SpA, and important unmet needs for future studies.


Key points








  • Juvenile spondyloarthritis can be viewed on a continuum with adult-onset disease.



  • Spondyloarthritis in children presents with peripheral arthritis and enthesitis more frequently than inflammatory back pain.



  • Sacroiliitis may be more common in children with juvenile spondyloarthritis than expected based on symptoms.



  • Validated measures of clinical disease activity, imaging, and biomarkers are needed to identify children with axial spondyloarthritis.



  • New therapeutic targets in the IL-23/IL-17 axis hold great promise for improving treatment options and outcomes in spondyloarthritis.


Only gold members can continue reading. Log In or Register to continue

Oct 1, 2017 | Posted by in RHEUMATOLOGY | Comments Off on Update on Juvenile Spondyloarthritis
Premium Wordpress Themes by UFO Themes