Lupus nephritis is a common complication of systemic lupus erythematosus in children and adolescents. This article reviews the clinical relevance of lupus nephritis and its current treatment. The reader is introduced to novel biomarkers that are expected to improve the management of lupus nephritis in the future, and support the testing of novel medication regimens.
Key points
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Lupus nephritis is frequently diagnosed in children with systemic lupus erythematosus and warrants close medical attention to avoid progression to end-stage renal disease.
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Diagnosis of lupus nephritis requires at present a kidney biopsy.
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Current laboratory tests used to monitor lupus nephritis lack accuracy, making appropriate management difficult.
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Novel urine biomarkers hold promise for improving the approach to the surveillance of lupus nephritis and interpretation of patient response to therapy.
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Despite the lack of adequately powered clinical trials, standardized approaches to the therapy for children and adolescents with lupus nephritis are now available.
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