Chapter 60 Contemporary thinking related to the meniscus focuses on preservation, restoration, and reconstruction. The menisci are critical for shock absorption, force transmission, and load distribution across the knee in addition to contributing to stability, joint congruence, articular cartilage nutrition, articular cartilage protection, joint lubrication, and proprioception. Because meniscus injuries often are irreparable, tissue engineering techniques have been used to develop acellular materials to support regrowth of lost meniscus tissue. For an engineered matrix to function as a resorbable meniscus template, of particular importance are the biomechanical properties of the matrix template because the template initially serves the biomechanical function of the meniscus. Thus strength of the engineered template and the subsequent biomechanical properties of the regenerated and remodeled tissue must be adequate for the device to survive initially in the hostile environment of the knee, and then ultimately to function like meniscus tissue. In addition, the scaffold must be conductive for cells as well as permeable to nutrients. Intrinsic biologic signals (e.g., growth factors) and cells must incorporate into the template to enhance the overall regeneration and remodeling process and provide an ideal biologic environment for cellular infiltration and new matrix synthesis. Specific indications and contraindications have been developed for meniscus scaffolds.1–13 • For use in patients with either acute or chronic meniscus injuries • Prior loss of meniscus tissue with intact anterior and posterior horn attachments and an intact rim over the entire circumference of the involved medial meniscus • Irreparable meniscus tears requiring partial meniscectomy and requiring greater than 25% removal and with the lesion extending at least into the red-white zone • Partial meniscus loss in the presence of early osteoarthritis (OA) with Kellgren-Lawrence grade 1 or 2 changes radiographically or Outerbridge grade III or lower changes arthroscopically • Anterior cruciate ligament (ACL) deficiencies corrected within 12 weeks of the implant surgery • Patients able and willing to follow postoperative rehabilitation program described later • Complete meniscus loss or absence of one or both horn attachments. • Uncorrected ligamentous instability or insufficiency in the involved knee. • Uncorrected Outerbridge grade IV (full-thickness) degenerative cartilage lesions and/or advanced OA in the affected joint. Limited clinical observations have suggested that the irregular surfaces of an untreated chondral lesion adjacent to the implant may damage or destroy the implant during the early stages of the regenerative process. No controlled studies have been conducted to confirm these observations, nor have studies been done to evaluate the consequences of having degenerative chondral lesions in other compartments of the involved joint that receives the scaffold. • Uncorrected malformations or axial malalignment in the lower extremity. Malalignment may excessively overload the involved compartment, possibly resulting in damage to the implant during the early regenerative process. No controlled studies have been conducted to confirm this possibility. Whether or not there is a coexisting OA with the malalignment, consideration should be given to correcting those abnormalities before or at least concurrently with the scaffold implantation. • Documented allergy to any product of animal or synthetic origin or a history of anaphylactoid reaction. • Systemic or local infection. • Medical history that is positive for, but not restricted to, severe degenerative osteoarthrosis, rheumatoid arthritis, relapsing polychondritis, or inflammatory arthritis. Two different meniscus scaffolds have been used clinically in humans and are in common use in several parts of the world. They are discussed in this chapter. Both the Collagen Meniscus Implant (CMI)1–8,11–13 (Ivy Sports Medicine, Montvale, NJ) as well as Actifit9,10 (Orteq Sports Medicine, London, United Kingdom) have comparable surgical implantation techniques. Therefore the techniques and steps described here pertain equally to both.
Meniscus Regeneration with Biologic or Synthetic Scaffolds
Preoperative Considerations
Indications
Contraindications
Surgical Technique