Ruscus aculeatus (Butcher’s Broom)

Chapter 119 Ruscus aculeatus (Butcher’s Broom)

Ruscus aculeatus (family: Liliaceae)

Common names: butcher’s broom, box holly, knee holly, kneeholy, kneeholm, Jew’s myrtle, sweet broom, pettigree, Maeusedornwurzelstock (German)

image General Description

Ruscus aculeatus (butcher’s broom) is an evergreen shrub native to Mediterranean Europe and Africa.1 It has rigid leaves that terminate in a single sharp spine. Its berries remain attached to the plant through the winter. The root, the part used medicinally, is thick, typically 2 to 4 inches long, with many woody rootlets growing on its lower surface.

image History and Folk Use

In ancient Greece, butcher’s broom was used as a laxative and to treat kidney stones.6 In Europe, a wine decoction of the root was used as a diuretic to treat urinary obstructions, kidney stones, and gravel. It was also used to regulate menses, ameliorate jaundice, and treat headaches. In South America, the roasted root was made into a beverage for prostate tumors.7

image Pharmacology

Antiinflammatory Effect

Butcher’s broom extract and its isolated steroidal saponins were antiinflammatory in several animal models.10 Injected intravenously, it inhibits the permeability increasing effects of bradykinin, leukotriene B4, and histamine in hamster cheek pouch preparations.11

Lymphatic Flow Effect

Butcher’s broom dose dependently enhanced the duration and flow intensity of the lymphatic vessels in dogs.14 This effect did not change when the calcium channel antagonist nifedipine was injected, indicating that butcher’s broom’s lymphatic effect does not involve the opening of calcium channels but appears to act directly on peripheral lymphatics.

Vasoconstrictive Effect

Topical administration of butcher’s broom extract in a hamster cheek preparation dose dependently inhibited histamine-induced increases in permeability.15 Research suggested that butcher’s broom’s vasoconstrictive effect is mediated by calcium and α-1 adrenergic receptors. Heat increases, and cold decreases, butcher’s broom’s ability to increase the release of norepinephrine from the adrenoreceptors.15

image Clinical Applications

There are few clinical studies on the effect of butcher’s broom alone. Instead, most of the clinical studies investigated a proprietary combination formula known as Cyclo 3 Fort by Pierre Fabre Medicament of Paris, France, or Phlebodril by Pierre Fabre Pharma GmbH of Freiburg, Germany. These formulas combine butcher’s broom with trimethylhesperidin chalcone (a flavonoid precursor) and ascorbic acid. Butcher’s broom has action independent of the other compounds in the formula, and some studies indicated that butcher’s broom used alone may have a stronger effect. However, other studies indicated that the combination may have a synergistic effect. All discussions of butcher’s broom trials in the following therefore include the possibility that it was not butcher’s broom by itself that was active.

Butcher’s broom is also paired with Melilotus spp. (sweet clover) in some topical preparations. There are no studies indicating whether butcher’s broom alone would achieve the same results.

Chronic Venous Insufficiency

Butcher’s broom is most commonly used to alleviate the symptoms of CVI, including ankle edema, itching, tension, and cramping of the legs. Both animal and clinical studies support its effectiveness in CVI, and the German Commission E approved butcher’s broom as an adjunct treatment for this condition.1 A meta-analysis evaluated 20 placebo-controlled, double-blind studies and 5 randomized trials against a comparator drug along with 6 single-arm studies without a placebo. The review included information on 10,246 subjects. Although data quality varied, Cyclo 3 Fort significantly reduced CVI symptoms compared with placebo.15a

Nine of these studies are summarized in Table 119-1.1624 All but two were randomized double-blind trials. In one large multicenter trial, 81.6% of treating physicians rated its efficacy as excellent, and the remaining physicians rated it as good.20 Butcher’s broom acts most strongly when circulation is impaired, but some researchers caution that it is less effective when the disease has compromised venous wall receptor activity.18

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Sep 12, 2016 | Posted by in MANUAL THERAPIST | Comments Off on Ruscus aculeatus (Butcher’s Broom)

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