Fig. 9.1
Subtrochanteric nonunion in irradiated bone with failed hardware
A careful history that evaluates systemic conditions and medications must be performed. The use of nonsteroidal anti-inflammatory drugs has been implicated in nonunion [7]. The inhibition of the cyclooxygenase pathway by nonsteroidals impairs the recruitment of cellular elements critical for the initiation of bone healing. Although intermittent use does not seem to impair healing, consistent dosing has been shown to delay union in animal models and in clinical series [8]. Screening for infection with a complete blood count, erythrocyte sedimentation rate, and C reactive protein may raise the index suspicion for infection although intraoperative culture is the optimal test. Nutritional status can be evaluated with albumin level and total lymphocyte count. Screening for vitamin D deficiency and other endocrine abnormalities should be considered [9]. Alternatively, referral to an internist or endocrinologist may assist in evaluation of metabolic contributors to nonunion.
Bisphophonates have been credited with reducing the risk of osteoporosis-related fractures and are commonly prescribed in the elderly population at risk these low-energy fractures. However, they have been implicated in atypical fractures of the femur, especially in the subtrochanteric area [10]. Their mechanism of action for reducing osteoporosis is by limiting osteoclastic resorbtion of bone. However, in so doing they may limit the critical function of bone remodeling contributing to the formation of atypical stress fractures of the femur often after 5 or more years of treatment, a time frame where continued use offers no added benefit. At present, there is no evidence that it impairs fracture union. However, authors have noted that these atypical fractures are prone to delayed union [10]. The role of anabolic agents such as synthetic parathyroid hormone to promote union especially in a patient with osteoporosis is not yet defined [11].
The surgical decision-making is specific for the femoral neck, intertrochanteric, and subtrochanteric regions. However, in developing the treatment plan for a nonunion, the surgeon must take into account not only mechanical factors but also biologic factors, local and systemic, as well as the patient’s functional needs. Balancing these issues with the potential risks of surgery will lead to a reasonable result. For instance, although preservation of native anatomy especially the femoral head is preferred, endoprosthetic replacement for failed treatment of femoral neck and intertrochanteric fractures may be the optimal treatment even in a patient under 65 after careful consideration of the expected treatment course and potential risks. In this discussion, the surgeon should not only consider the quickest or most straightforward treatment option but also keep in mind the consequences of failure of the chosen course. With prosthetic replacement, the potential for dislocation, periprosthetic fracture, and the devastating effect of infection must be taken into account. The patient and surgeon must maintain awareness of the potential for such outcomes. In select cases, Girdlestone resection arthroplasty with its attendant limitations may remain the best treatment option for problematic proximal femur nonunion especially in the face of recalcitrant infection or a patient with significant comorbidities or low functional demand [12].
9.1 Femoral Neck
Among fractures of the proximal femur, the femoral neck is the most prone to nonunion. Although one series reported a nonunion rate of 59% and avascular necrosis rate of 86% [13], most authors have reported nonunion rates as of 0–30% in young patients [14–16]. Union is expected within three months of fixation although failure can be seen very early following fixation particularly in inadequately fixed fractures or noncompliant patients. These early failures should be considered as a nonunion even though 3 or 6 months have not passed from the time of fixation. Even surgically repaired nondisplaced fractures have been noted to proceed to nonunion in up to 8% of cases indicating the multifactorial nature of nonunion [17, 18]. The risk of fixation failure in elderly patients with displaced fracture has led to the recommendation for arthroplasty to avoid multiple procedures and prolonged disability [19]. The propensity for nonunion can be attributed to biologic and mechanical factors. The femoral neck is intracapsular and lacks periosteum, an important contributor to fracture healing. The blood supply enters through the circumflex vessels, which may be disrupted by the injury and surgery [20, 21]. Not only may vascular disruption impair fracture healing, but it may also contribute to avascular necrosis.
In femoral neck fractures, the development of a nonunion is usually heralded by loss of reduction especially varus collapse. Varus is particularly unstable, leading to continued collapse and ultimately failure. In this instance, the surgeon should consider early revision. Shortening along the axis of the cannulated screws or screw and side plate is often seen and may result in union. However, progressive shortening without evidence of stabilization is a sign of nonunion. Ultimately, the fixation device may end up within the hip joint and failure requiring revision (Fig. 9.2). Although any varus collapse should alert the surgeon for potential revision, Alho et al. [22] suggested specific radiographic criteria of failure. High rates of revision were associated with a change in reduction of 10 mm, change in screw position by 5%, or screws backing out by 20 mm .
Fig. 9.2
Progressive failure of femoral neck “valgus impacted” fracture with hardware encroaching the joint. Note failure into varus and screws backing out (a, b)
Mechanically, the femoral neck is subject to substantial forces while depending on its trabecular structure for mechanical strength [21]. Certain patterns of injury, namely the vertically oriented fracture, are prone to nonunion because of poorly controlled shear forces [23]. The Pauwels classification scheme based on the angle of the fracture line to the horizontal defines 3 types: low, < 30 degrees; intermediate, between 30 and 60 degrees, and high, greater than 60 degrees (Fig. 9.3). Regardless of fracture pattern, fixation strategies that do not engage subchondral bone will have limited ability to control this short bone segment. The optimal treatment device has not been definitively established with proponents of sliding screw and side plates and those favoring cannulated screws [24]. At present, data suggest that sliding screw and side plate devices may be less prone to failure but may have a higher rate of avascular necrosis. In the case of cannulated screws, placing the device adjacent to the cortex improves fracture stability by increasing screw spread and by taking advantage of cortical bone. Placing cannulated screws more centrally has been compared to placing them in an “empty can” in the elderly patient contributing to fixation failure [25] .
Fig. 9.3
Pauwels classification: Line A is drawn in line with the femoral shaft; line B is drawn perpendicular to line A. Lines C and D represent possible femoral neck fracture lines. The angle created by line C or D to the perpendicular determines the Pauwels type: Pauwels 1, <30 (line C); Pauwels 2, 30–60; Pauwels 3, >60 (line D)
The quality of reduction is a determinant of stability [14]. Fractures with poor reduction, especially varus, have impaired mechanics and are prone to failure. In the young patient where retention of the hip is critical, the surgeon should strive for an anatomic reduction. Therefore, open reduction is advocated since closed reduction may not consistently achieve this goal. The exception to this rule is a valgus impacted fracture, usually seen in the elderly patient. This fracture pattern is considered stable and is fixed in situ.
9.1.1 Surgical Options
Options for revision in femoral neck fractures nonunion are arthroplasty or revision fixation with or without osteotomy. In the older patient, arthroplasty is the primary form of treatment, while a younger patient should be considered for revision fixation. There is no particular age at which revision fixation or arthroplasty should be done. Marti successfully performed osteotomies up to age 70, while arthroplasty surgeons have advocated replacement at age 60–65, especially as arthroplasty implants have improved and patients are less tolerant of lengthy rehabilitation [16, 19]. Careful consideration of expected clinical course and potential complications should be used in choosing treatment (Table 9.1) [26–34]. Revision fixation requires a healing period prior to the resumption of activities, which may last 3–6 months and does not guarantee success. However, it allows for preservation of the native hip joint. Even the presence of low-grade avascular necrosis is not a contraindication to hip preservation [15, 26, 31]. In the uncommon instance of biologic failure, the healing environment can be augmented by autogenous or vascularized bone graft. The Meyers graft [35, 36] which utilizes the bony insertion of the quadratus femoris placed into the posterior femoral neck or a vascularized fibula as advocated by LeCroy et al. [31] can provide the stimulus to achieve union.
Table 9.1
Comparative table of treatment of femoral neck nonunion
Study | Number | Age | Avg time from index surgery (mos) | Technique | Follow-up | % Union | Complications | Outcome |
---|---|---|---|---|---|---|---|---|
Marti et al. [26] | 50 | 19–76 | 9 (2−60) | Osteotomy; 120° double-angle blade plate, local bone graft | 7.1 (3–13) years | 86 | 3 UTI, 3 DVT, 1 deep infection (ankylosis) 14% THR (3 nonunion, 3 AVN, 1 failed hardware (Etoh abuse) | Harris score 91, Merle D’Aubigne 78% good to excellent; AVN in 22 pts, 3 requiring THR, |
Anglen et al. [27] | 13 | 34 (18–59) | 21 (4–54) | Osteotomy; 120 deg double-angle plate, local bone graft | 2 years (0.7–3.5) | 100% | AVN in 2 pts-THR | Harris 93, no pain 7/8 return to work, avg LLD 1.5 cm |
Shoenfeld et al. [28] | 4 | 35 (24–42) | 6 | Opening/closing wedge osteotomy; cannulated 130–140° sideplate, local bone graft | 1.25 (0.25–2.3) years | 100% | None | Merle D’Aubigne 16.5; cane 1 pt, no LLD but sl Trendelenburg 2/4 |
Hartford et al. [29] | 8 | 46 (30–65) | 10 | Closing wedge, cannulated 135–155 sideplate, local bone graft | 2 years | 88% | Unrelated death at 4 months | Harris hip score 73, cane 1 pt. Trendelenburg 4/7 |
Said et al. [30] | 17a | 37 (18–49) | 130 single-angle blade, closing wedge | 3.5 (1–5) | 97%a | AVN 5 cases 1 THR for nonuniona | 61% pain free, LLD < 0.5 cma | |
Lecroy et al. [31] | 22 (all with AVN at presentation) | 28.7 | 18.3 | Free fibula, cannulated screws | 7 years | 90% | 2 nonunion (1 iliac crest graft, 1 Meyers graft); 4 hardware removal for articular penetration | 60% progression of AVN but 90% retained native hip, Harris score 78.9 |
Jun et al. [32] | 26 | 41 (22–60) | 12 | Free fibular in anterior trough | 3.5 (1–5) years | 100% | 1 infection, 1 AVN (THR) | Harris score 88 |
Elgafy et al. [33] | 17 | 46 (24–58) | 8 (4–22) | 13 autograft non-vascularized fibula; cannulated screws | 69% | 4 nonunion-arthroplasty, 2 ankle pain | ||
6 allograft fibula; cannulated screws | 33% | 3 arthroplasty, 1 autograft fibula | ||||||
Wu et al. [34] | 26 | 38 (17–60) | 1.4 (0.8–2) | 17 osteotomy with sliding screw | >2 years (2–6) | 100% | 2 AVN, 1 nonunion osteotomy | Osteotomy indicated if shortening was >1.5 cm |
9 sliding screw only | 100% | None |
9.1.2 Revision Fixation
Mechanical failure is most common with failure of fixation and development of a deformity on radiographic examination. In femoral neck nonunion attributed to mechanical failure, the principal decision is whether osteotomy will improve the mechanical environment. On analysis of the nonunion, the new construct must assure adequate stability in the face of physiologic forces to allow for healing. In the instance of a poorly placed initial construct, revision fixation alone may be considered. Cannulated screws in the most optimal position or a screw and side plate device with screw augmentation may allow for healing. Wu, in a mixed series with and without osteotomy, reported 100% healing in the group treated with a screw and side plate alone [34].
9.1.3 Valgus Osteotomy
In high angle fractures often seen in the younger patient, an osteotomy is indicated when a nonunion develops. These nonunions are often associated with varus and shortening. Properly executed osteotomies result in union rate of 70–100% [26–29, 34]. As described by Pauwels, the osteotomy converts a vertically oriented fracture with shear to a more horizontal orientation creating compressive forces promoting union. In considering an osteotomy, the duration of healing along with alterations of anatomy must be considered. These alterations of shortening and a lesser abductor moment are generally well tolerated but should be discussed with the patient.
In this procedure, the nonunion is not exposed directly. A blade plate is most often used to compress the osteotomy, but a screw and side plate may also be used [28, 29, 34]. A blade plate is technically more demanding but offers proven stability while requiring only a narrow corridor of bone.
The critical step in performing the intertrochanteric osteotomy is preoperative planning (Fig. 9.4). The concept is to convert the angle of the fracture to less than 30° by performing an intertrochanteric osteotomy. Good anteroposterior pelvis and lateral hip views are required. The angle of the fracture to the horizontal is measured. Due to leg rotation, the precise angle may be hard to measure, but may be facilitated by measuring it to a line perpendicular to the femoral shaft [27]. A closing wedge osteotomy is planned to correct the angle of the fracture to less than 30°. In the case of a fracture angle of 70°, a wedge of 40° is planned.
Fig. 9.4
Corrective osteotomy of femoral neck nonunion: a injury radiograph note vertical angle; b initial fixation; c nonunion, note varus, and shortening; d surgical template—fracture angle is 70°, a 40° correction will result in an angle of 30°, and osteotomy is planned 1.5 cm distal to projected blade insertion site; e intraoperative templating; f placement of chisel anteroposterior view; g placement of chisel lateral view; h healed nonunion and osteotomy
The position of the blade plate that allows for adequate fixation is templated. Inevitably, the biomechanics of the hip are altered with some shortening of the neck and medialization of the shaft. Some modifications of the osteotomy have been proposed that can minimize the anatomic alterations. A combination of opening and closing wedge osteotomy or translating the shaft laterally along the osteotomy are methods used to limit biomechanical alterations but may carry a theoretic risk of nonunion.
The intertrochanteric osteotomy is executed on a radiolucent table. The surgeon must assure adequate radiographic visualization of the hip prior to create the sterile field. The proximal femur is exposed through a lateral approach, but the nonunion site is not opened. The previous hardware is removed. The projected osteotomy site is marked as well as the position of the fixation device. The pathway for proximal fixation should be established prior to the osteotomy since it is very difficult to place a blade plate after the osteotomy is completed. For a blade plate, a guide wire and drill bits establish the pathway for the chisel. The pathway starts on the greater trochanter skirts the piriformis fossa, across the nonunion and terminates in the inferior medial femoral head. The chisel is used to create a pathway for the blade plate. Frequent fluoroscopic views in both the anteroposterior and lateral views assure that correct placement.
The planned closing wedge osteotomy is marked with Kirschner wires. The proximal cut is parallel with the blade plate track and at least 1.5–2 cm distal to provide for a bone bridge. The osteotomy is then performed with a saw while cooling the blade with irrigation making sure not to cause thermal necrosis. It is also important to keep the osteotomy perpendicular to the shaft to avoid flexion or extension. The selected blade plate is seated, and then, the osteotomy is compressed with a compression device placed distally on the shaft. On the anteroposterior view, care is taken to avoid excessive medialization along the osteotomy as it contributes to not only to limb shortening but also to loss of abduction and valgus alignment of the knee. A longer blade and lateralization of the shaft limits this problem. Close attention is paid on the lateral view and rotation to assure that these are maintained in final fixation. Displacement in the lateral view will render subsequent arthroplasty if needed much more difficult. The harvested wedge is morselized and placed around the osteotomy site. Postoperatively, touch weight bearing and then protected weight bearing are allowed until healing is seen, usually in 3 months. Patients are cautioned that persistent limp and mild leg length difference are common while preserving the native hip.
Results of valgus intertrochantgeric osteotomy have been reported by a number of authors consistently reporting union from 70 to 100% of patients with avascular necrosis occurring around 20% [26–29, 34]. Marti et al. in a series of 50 patients with a mean age of 53 achieved a union rate of 86% [26]. Of 22 patients that had evidence of osteonecrosis without collapse only 3 progressed requiring arthroplasty. An additional 3 patients required arthroplasty for continued nonunion and one for periprosthetic fracture for an arthroplasty rate of 14% with a mean follow-up of 7 years. In this series, the Harris hip score was 91, while 78% were good or excellent on the Merle d’Aubigné score. Anglen had 100% union rate in 13 patients although 2 required arthroplasty by 2 years for osteonecrosis [27]. Ballmer et al. reported that in 17 patients, 71% healed following the index procedure while an additional 3 healed following additional bone grafting for an overall union rate of 88% [37]. Three, however, required subsequent arthroplasty for avascular necrosis. In Hartford et al.’s series of 8 patients treated with a sliding hip screw union was achieved in all cases and Harris hip score improved from 24 to 73 [29]. Another more recent series reported the use of a single-angled 130 degree plate [30]. In 36 patients (mean age 37), union was achieved in 97%, while 5 developed avascular necrosis. 61% reported no pain, and the average leg length deficit of 2.5 cm was corrected to 0.5 cm. The authors of this series felt that the single-angle plate limited medialization while optimizing length. Other authors, using the double-angle plate, have been able to control this problem by laterally translating the femur. Unfortunately, more detailed outcomes measures are not available to judge functional status or compare methods of treatment.
9.1.4 Vascularized Graft
A vascularized fibular strut or vascular iliac crest has been proposed to enhance vascularity while correcting deformity and enhancing stability [31, 38, 39]. The fibular technique has been particularly advocated in nonunions with associated avascular necrosis provided the acetabulum is intact, but this is technically demanding and requires microvascular anastomosis.
The surgical technique described involves removal of hardware and revision fixation. Through a Watson-Jones approach, a channel is created in the lateral femur into the neck and head to accommodate the harvested fibula. The necrotic bone in the head if present is removed with special burrs. Correction of the femoral neck deformity is obtained from the mobility gained when the channel is created. The defect in the head is filled with cancellous bone from the greater trochanter. The fibula is placed into the head and neck and stabilized with a K-wire after the fibula is inserted. The critical vascular anastomosis is then performed. Further stability is obtained by placing cannulated screws parallel to the free fibula. Postoperatively the patient is nonweight bearing for 6 weeks and then gradually progressed thereafter. This technique is clearly technically demanding but is useful in the face of avascular necrosis.
The series reported by LeCroy et al. describes 22 patients (mean age 29) who underwent a vascularized fibula repair of a nonunion at a mean of 18 months following initial fixation [31]. Union was achieved in all patients at an average of 9 months but 2 required additional surgeries to achieve union. Osteonecrosis was present in all 22 cases at reconstruction surgery (predominantly Steinberg Stage II, 12 cases, but also Stage I, 4 cases; Stage III, 2 cases; Stage IV, 3 cases; even Stage V, 1 case). Despite osteonecrosis progressing in 13 patients, the native hip was retained in 20 patients with an average Harris hip score of 78.9. Although only 5 reported being able to participate in vigorous physical activity that included running, 16 were able to perform moderate activity.
Recently, an alternate method of free vascularized fibula was reported by Jun and colleagues [32]. In the reported series of 26 cases, the free fibula was inserted via an anterior approach into a trough facilitating placement and simplifying vascular re-anastomosis. Twenty-four healed at an average of 5 months. One case of postperative osteonecrosis was observed. Unlike the series of Lecroy where all had osteonecrosis, in this series only 1 patient had radiographic findings of osteonecrosis preoperatively. Outcomes were reported in terms of the Harris hip score, which improved on average to 87.9.
The use of nonvascular fibular grafts has been reported by Elgafy and associates in 19 cases with minimal varus malalignment [33]. In that small series, nonvascular fibular sutografts achieved union in 9 of 13 cases (69%). The same authors reported union in only 2 of 6 cases in which a fibular allograft was used. Despite the relative technical ease of such a technique, there is no advantage in using a nonvascular fibular strut in the treatment of femoral neck nonunion.
9.1.5 Arthroplasty
Arthoplasty particularly with modern bearing surfaces should be considered in femoral neck nonunion not only in the face of acetabular destruction or avascular necrosis. In the patient over 60, arthroplasty is likely to provide a reliable method to return the patient to activity but does not match the excellent results achieved with primary arthroplasty for osteoarthritis. Although in the series of Marti et al. osteotomy was generally preferred in patients up to age 70 [26] and by Hitt to age 60 [19], modern techniques and implants have lowered the age in which arthroplasty is considered. Particularly in the younger patient, considerations should include the potential for infection, dislocation, and periprosthetic fracture. Although the incidence for each of these complications is low, for the patient with an infection, for instance, the outcomes are greatly diminished. It is well established that arthroplasty in the face of previous surgery raises the risk of infection [40].