7 Leech Therapy in Plastic Surgery In modern medicine, corrective plastic surgery is mainly indicated for reconstruction of cutaneous defects caused by accidents, burns, tumor resection, and postoperative wound-healing disorders. Reconstructive plastic surgery is also frequently required for elimination of functional deficits associated with scar contracture. The range of corrective surgery includes repairs using local skin flaps (proximal flaps), such as advancement and rotation flaps. Reconstructive surgery, on the other hand, encompasses the use of local skin flaps with a vascularized pedicle (e.g., pectoralis major flaps and latissimus dorsi flaps), as well as microsurgical tissue transfers using graft material from adjacent and distant sites. Unlike the other techniques, microsurgical tissue transfer and replantation surgery require a complete interruption of blood flow to the vascularized tissue pedicle. In some cases, the blood supply must be interrupted for several hours. The blood vessels (arteries and veins) that supply the grafted tissues must therefore be reconnected by microscopic anastomosis. Latissimus dorsi flaps are frequently employed as microsurgical transplants, especially in plastic reconstruction of large defects. In all of these techniques, the blood supply to the grafted tissues must be partly or completely (microsurgical transplants) interrupted and redirected. Traction or pressure-related changes in tissue tension or changes in blood flow patterns can therefore lead to impaired perfusion in the grafted tissues. Failure of the vascular anastomosis is one of the most feared complications of microvascular surgery. Thrombosis or insufficiency of anastomosed arte ries can have various causes, such as collapse or spasm of the affected vessels. Thrombosis or insufficiency of anastomosed veins occurs less frequently. Ischemia is a typical sign of arterial thrombosis. When this complication occurs, the transplant turns visibly pale during surgery or within a few hours after surgery. If one briefly applies gentle pressure to the ischemic transplant with one’s finger (or a cotton swab), the return of capillary blood flow to the affected region will be significantly delayed or absent after one releases the pressure. If the arterial blood supply remains interrupted or inadequate, the graft will die within a few hours to days, depending on the temperature of the transplant. An ischemic transplant will sometimes have a marbleized or grayish blue appearance and a pale center. Failure of blood to emerge from an exploratory incision or puncture confirms the suspicion of ischemia. If arterial complications occur, revision of the vascular anastomosis must be performed as quickly as possible. Ischemia is frequently caused by insufficiency of the reconnected vessels, but may also be due to vessel wall injury or trauma-related vasospasm. Since hypoxia and electrolyte imbalances may also induce vasospasms, electrolyte testing should be performed regularly during the postoperative period. However, in many cases the exact cause cannot be determined. Patients at risk for these complications should be monitored in the intensive care unit (ICU). Hemoglobin levels should also be measured to ensure adequate oxygen transport and to determine whether a blood transfusion is required. Oxygen tissue pressure in the transplant should be monitored by intravital microscopy. In pedicle flaps, perfusion problems may develop, but imbalances between arterial supply and venous drainage are more common. Deficient venous return leads to venous congestion or—in the worse case–thrombosis. Blue discoloration of a transplant is the classic sign of venous congestion. The skin becomes increasingly mottled, especially in areas with the worst blood drainage, which is usually along the edges of the transplant. If the drainage problem persists, discoloration increases, and the transplant changes from violet to blue to black. Significant volume enlargement of the transplant further aggravates the venous insufficiency problem. Transplant patients should therefore be monitored at frequent intervals (in the ICU), particularly in the first few hours and days after surgery. Potential complications can then receive immediate and continuous attention. Leeching has been used for decades to alleviate perfusion problems in skin grafts, and the efficacy of leeching in this indication has been repeatedly demonstrated. Since the 1980s, leech therapy has regained recognition in the medical literature after initial publications by Upton’s group in the United States and Mahaffey’s team in Europe gave this treatment modality new impetus. A publication that significantly contributed to this development and awakened the general interest in leeching in plastic surgery was a case report about the successful use of medicinal leeches to salvage the reattached ear of a boy in the United States [4]. In 1985, the right ear of a five-year-old boy from Medford, Massachusetts was bitten off by a dog. After several hours of surgery, his doctors succeeded in reattaching the ear. The blood vessels of the ear were reconnected by microscopic anastomosis. Microsurgical anastomosis of arteries requires a great deal of skill on the part of the surgeon, and reattachment of hair-thin veins, which are usually collapsed in these cases, is extremely challenging. The chances of the ear surving were slim, although one artery and multiple veins had been anastomosed. The reattached ear soon developed symptoms of venous insufficiency and started to turn blue and swell. Dr. Upton, the attending Army surgeon, applied several leeches to the affected ear region to relieve the venous congestion. His only experience with leeches until then had been in the treatment of poorly perfused skin grafts. The circula-tory situation in the reattached ear then improved rapidly, and the boy was discharged from the hospital with an intact ear. Historically, the successful use of leeches, especially Hirudo medicinalis, for treatment of insufficient flap perfusion following plastic surgery, particularly facial surgery, has been known for over a century. The first reports in the literature describe the successful application of medicinal leeches to restore circulation in nasal skin grafts [1] and skin flaps threatened by venous congestion [2]. Dieffenbach (1792–1847), a Berlin surgeon accredited as one of the fathers of modern facial surgery, also described the successful use of leeches after plastic surgery in 17 cases [7].
Theory