Femoral Internal Fixation and Metastatic Bone Disease



Femoral Internal Fixation and Metastatic Bone Disease


Timothy A. Damron



Metastatic disease (including myeloma and lymphoma) involving the femur requires a different approach from that for primary bone disease. In most cases, resection for cure is not the goal; rather, palliation and maintaining function are the goals. In the femur, except for femoral neck fractures or extensive replacement of the proximal femur by tumor, internal fixation is usually indicated for metastatic bone involvement. Most cases warrant a third-generation “reconstruction” type of femoral nail to protect the entire femur, but for solitary lesions in the intertrochanteric region, some surgeons prefer the dynamic hip screw and cement. Unless otherwise indicated, this chapter focuses on the third-generation nail; where there are differences with the dynamic hip screw, those are noted in each section.





CONTRAINDICATIONS


Third-Generation Intramedullary Reconstruction Nail

Contraindications also involve the location of the tumor, the quality of the proximal and distal remaining femoral bone, and the patient’s life expectancy (Table 13.1). All medical issues should be addressed preoperatively and optimized.


Dynamic Hip Screw Device Contraindications

In addition to those contraindications above, the dynamic hip screw device is contraindicated for the following pathologic fractures and lesions:



  • Any anatomic site other than the intertrochanteric region


  • Presence of additional lesions elsewhere in the femur away from the intertrochanteric region that may develop problems if they progress


  • Inadequate proximal diaphyseal bone to provide secure screw fixation








TABLE 13.1 Contraindications and Alternative Surgical Options for Third-Generation Intramedullary Nail Fixation of the Femur





























Category


Contraindication


Alternative Surgical Treatments


Location


Femoral neck fractures


Prosthetic hip endoprosthesis: hemiarthroplasty vs. total hip arthroplasty



Distal femoral metaepiphysis lesions or fractures


1. Plate/screw fixation alone or supplementing reconstruction femoral nailinga


2. Distal femoral megaprosthesis total knee replacement


Bone Quality


Insufficient proximal femoral bone stock


1. Prosthetic hip endoprosthesis: hemiarthroplasty vs. total hip arthroplasty


2. Calcar replacement stem (hemi vs. total)


3. Proximal femoral megaprosthesis



Insufficient distal femoral bone stock


1. Plate/screw fixation alone or supplementing reconstruction femoral nailinga


2. Distal femoral megaprosthesis total knee replacement


Life expectancy <6 wk



Hospice care


a Retrograde nailing may be considered in this situation, but only with great caution, as it leaves the proximal femur unprotected (Fig. 13.2).







FIGURE 13.2 Retrograde femoral nails are not ideal for internal fixation of impending or actual pathologic femur fractures as they fail to adequately protect the proximal femur, a common site of bone metastases. This patient incurred a pathologic right distal femur fracture above a total knee arthroplasty. A,B. Biopsy showed metastatic carcinoma, and the patient underwent surgical stabilization utilizing a retrograde femoral intramedullary nail without bone cement supplementation. C: Subsequently the patient developed a second pathologic fracture through the proximal femur just above the retrograde femoral nail in the region left unprotected by the original stabilization.



PREOPERATIVE PLANNING



  • Confirm diagnosis



    • Preoperative metastatic workup to search for likely primary and identify extent of disease (if unknown)



      • Total skeleton bone scan


      • Computerized tomography of chest/abdomen/pelvis


    • Serum protein electrophoresis and urine protein electrophoresis to evaluate for multiple myeloma


    • Establish diagnosis of femoral lesion with tissue before proceeding with treatment (unless patient already has had tissue documentation of other bone metastases)



      • Preoperative needle biopsy


      • Intraoperative needle or open biopsy with frozen section


  • Assess extent of bone defect and remaining bone, proximal and distal



    • Plain biplanar radiographs of entire femur


    • Consider MRI or CT to assess extent of defect


  • Entertain alternative means of operative management



    • Consider alternatives if proximal (more likely) or distal bone proves inadequate to support fixation intraoperatively (Table 13.2)



      • Supplementation with bone cement


      • Proximal endoprosthetic device


    • Decide upon a backup plan and have implants available (see Table 13.2)


  • Ensure all equipment will be available



    • Primary plan: third-generation femoral reconstruction nail (or dynamic hip screw) of choice with insertion equipment, flexible intramedullary reamers and guide rod(s), radiolucent fluoroscopy table or fracture table, and c-arm fluoroscopy


    • Backup plan(s): bone cement with insertion device of choice (Toomey syringe), third-generation intramedullary reconstruction nail (if primary plan involves dynamic hip screw device), endoprostheses, and associated insertion equipment (see Table 13.2)


  • Consider preoperative embolization (Fig. 13.3)



    • Vascular malignancies: renal carcinoma, thyroid carcinoma, and myeloma


    • This is particularly important to consider for these techniques because whether the lesion is approached directly or indirectly (reaming through it), brisk bleeding may be encountered.


TECHNIQUE


Third-Generation Intramedullary Reconstruction Nail (Fig. 14.4A-P)

Positioning A radiolucent table should be utilized. For impending fractures, a Jackson table or other equivalent vascular imaging table without metallic bars on the side that may impede fluoroscopic imaging is ideal (Fig. 13.4A and B). When traction is desired, as with displaced pathologic fractures, a fracture table is often preferable. In either case, the table should be chosen to minimize interference with intraoperative imaging. Typically, the patient is positioned supine with a bump under the operative hip (Fig. 13.4B). The ipsilateral arm should be secured over a pillow across the patient’s chest to avoid interference during intramedullary instrumentation.


Landmarks



  • Tip of greater trochanter. Adequate access to the region proximal to the tip is crucial, so attention must be paid to this when placing the bump under the hip during positioning and also during draping.


  • Rotational landmarks: Anterior superior iliac spines, patella, and lateral femoral condyle should be assessed to ensure that postoperative rotation is optimal when dealing with displaced fractures.








TABLE 13.2 Reconstructive Alternatives to Internal Fixation Devices Based on Anatomic Region of Compromised Proximal Femoral Bone















Anatomic Region with Compromised Bone (from Femoral Head Down to Designated Level)


Reconstructive Alternative


Base of femoral neck


Standard or long-stem cemented femoral stem


Inferior aspect of lesser trochanter


Calcar replacing cemented femoral stem


More distal


Proximal femoral replacement megaprosthesis








FIGURE 13.3 For metastatic lesions of the femur due to renal carcinoma, myeloma, or thyroid cancer, consideration should be given to preoperative embolization to minimize intraoperative bleeding. A: This patient with known metastatic thyroid cancer to the left femur subtrochanteric region with impending pathologic fracture had associated pain despite treatment with radioactive iodine. B: Considerable intraoperative bleeding was encountered during placement of this locked third-generation reconstruction nail (Long Gamma Nail, Stryker).


Surgical incision



  • To establish diagnosis. If a biopsy is to be done as part of the procedure, the approach should be from the lateral thigh directly at the site of the lesion, NOT through the intramedullary canal (Fig. 13.4C)! The frozen section diagnosis should be established unequivocally to be metastatic disease, myeloma, or lymphoma before proceeding to operative fixation. If there is a possibility that the diagnosis represents sarcoma, the procedure should be aborted until a definitive diagnosis is rendered on permanent sections.


  • For third-generation intramedullary nail insertion through the tip of the greater trochanter



    • Depending upon the size of the patient, the incision may vary from 2 to 6 cm.


    • Begin the incision at the center (anterior-posterior) of the tip of the greater trochanter and extend proximally.






FIGURE 13.4 A: A typical intraoperative setup for femoral trochanteric nailing of an impending fracture is shown here. The patient is positioned on a radiolucent Jackson table to facilitate intraoperative imaging, the surgeon and assistants are on the operative side (patient’s right in this case), the fluoroscopy c-arm unit is coming in from the patient’s contralateral side (patient’s left in this case) to minimize interference with the use of instruments by the surgeon, and the viewing screen at the foot of the bed where it is unobstructed by other personnel or equipment. B: When there is no fracture, a fracture table is unnecessary, as in this case of an impending pathologic fracture. In a supine position with a bump under the operative hip to facilitate access to the trochanteric region, the operative limb may be easily manipulated to allow exposure to the lateral biopsy/curettage site (the larger midshaft incision in this case) as well as to the tip of the trochanter, as shown here for insertion of instruments and the implant into the femoral canal. The operative limb is adducted and internally rotated to bring the tip of the greater trochanter more anterior. In much the same manner, the limb can also be easily manipulated to obtain both anteroposterior and frog-lateral x-ray views with the fluoroscopy unit. This obviates the cumbersome and time-consuming rotation of the fluoro unit much of the time.

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Jun 13, 2016 | Posted by in ORTHOPEDIC | Comments Off on Femoral Internal Fixation and Metastatic Bone Disease

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